Dr. Donald Ingber

Professor of Bioengineering, Harvard John. A. Paulson School of Engineering & Applied Sciences

Biologically Inspired Engineering: From Human Organs-on-Chips to Programmable  Nanotherapeutics

Dr. Donald Ingber

Professor of Bioengineering, Harvard John. A. Paulson School of Engineering & Applied Sciences

Abstract

The Wyss Institute for Biologically Inspired Engineering at Harvard University that I lead has pioneered a new model for innovation, trans-disciplinary collaboration and technology translation. I will highlight engineering of “Organs-on-Chips” that recapitulate organ-level structure and functions as a way to replace animal testing for drug development, mechanistic discovery, and personalized medicine; nanotherapeutics that target to vascular occlusion sites like artificial platelets; anticoagulant surface coatings for medicine devices inspired by a plant; a ‘biospleen’ device that cleanses blood of pathogens and toxins in septic patients; and self-assembling DNA-based nanorobots that can be programmed to travel to cancer sites and kill tumor cells. This new bioinspired technology wave represents a major paradigm shift in medicine, and the novel organizational structure of the Institute offers an entirely new way to translate discoveries into breakthrough products in the academic setting.

Dr. Donald Ingber is the Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University the Judah Folkman Professor of Vascular Biology at Harvard Medical School & Boston Children’s Hospital, and Professor of Bioengineering, Harvard John. A. Paulson School of Engineering & Applied Sciences. He is a member of the National Academy of Medicine, National Academy of Inventors, American Institute for Medical and Biological Engineering, and American Academy of Arts and Sciences.

Dr. Donald Ingber

    Professor of Bioengineering, Harvard John. A. Paulson School of Engineering & Applied Sciences