Dr. Sheldon Weinbaum

Dr. Sheldon Weinbaum

Micro-CT Analysis of a New Paradigm for Vulnerable Plaque Rupture: Cellular Microcalcifications in Fibrous Caps

Dr. Sheldon Weinbaum

Abstract: 

 Nearly 60% of all deaths due to cardiovascular disease in the U.S. are due to the sudden rupture of thin cap fibroatheroma (TCFA). TCFA is the fibrous cap overlying the necrotic core of a vulnerable plaque within coronary arteries. This presentation will focus on a new hypothesis for TCFA rupture, namely due to stress-induced debonding of minute calcifications, the size of a single cell whose dimensions are much smaller than large calcifications which are much more stable. Analysis via confocal microscopy and micro-computed tomography (CT) imaging indicates that cellular calcifications of thickness less than 80 microns are most vulnerable in areas of high background stress, such as those occurring in bends or if the microcalcification is oriented along the tensile axis.
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Dr. Sheldon Weinbaum is the City University of New York (CUNY) Distinguished Research Professor, is widely recognized for his contributions in re-entry aerodynamics, basic studies in fluid mechanics, and transport and cellular level biomechanical phenomena in the human body. He is the only engineer to have received a Guggenheim in the area of cell and molecular biology and is one of eight living individuals elected to all three U.S. National Academies, the National Academy of Engineering, the National Academy of Science, and the Institute of Medicine.

Dr. Sheldon Weinbaum
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