Weiyong Gu

Photo of Weiyong Gu

Weiyong Gu

Professor | College of Engineering | Mechanical and Aerospace Engineering Department
Work Phone: (305) 284-8553

Website: Tissue Biomechanics Laboratory
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Biography

Dr. Weiyong Gu is a professor of the Department of Mechanical and Aerospace Engineering. Previously, he served for 13 years as a professor in the University’s Department of Biomedical Engineering. Gu is an internationally recognized researcher in biomedical engineering, in particular in the field of soft tissue biomechanics and mechanobiology, with an expertise in computer modeling of human intervertebral discs for diagnosis and in-silico clinical trials. Over the past 20 years, Gu has developed new theory and constitutive relations for transport and mechanical properties of soft tissues; new computational methods for quantitatively investigating chemical, electrical and mechanical signals within cartilaginous tissue under mechanical loading; and innovative experimental techniques for biomechanics and mechanobiology of intervertebral disc tissues. Gu has published more than 180 papers, abstracts and book chapters in the areas of tissue mechanics, transport phenomena, computational biomechanics, and intervertebral disc nutrition and degeneration. Gu received his PhD in mechanical engineering from Columbia University in 1994. In 1998 Gu joined the University’s College of Engineering as an assistant professor in the biomedical engineering department after completing postdoctoral training and serving as an associate research scientist in the Department of Orthopaedic Surgery, College of Physicians and Surgeons at Columbia University. Since then, he has served as director of the tissue biomechanics laboratory. The National Institutes of Health has funded Gu’s research with grants totaling more than $2.5 million. He is a fellow of the American Society of Mechanical Engineers and a member of the Orthopaedic Research Society and the Biomedical Engineering Society.

Research Interests

Tissue Biomechanics; Transport Phenomena; Continuum Mixture Theory; Computational Biomechanics; Mechanobiology of Intervertebral Disc; Bioreactor Technology

HIGHER EDUCATION

    • Columbia University, NY, Ph.D. in Biomechanics (1993)
    • Columbia University, NY, M. Phil. in Mechanical Engineering (1991)
    • Shanghai Jiao Tong University, Shanghai, China, M.S. in Engineering Mechanics (1986)
    • Shanghai Jiao Tong University, Shanghai, China, B.S. in Engineering Mechanics (1983)

EXPERIENCE

    • University of Miami , Professor (secondary) of Biomedical Engineering. Biomedical Engineering (2010 - Present)
    • University of Miami , Professor and Chair. Department of Mechanical and Aerospace Engineering (2011 - 2017)
    • University of Miami , Associate Professor of Biomedical Engineering. Biomedical Engineering (2004 - 2010)
    • University of Miami , Assistant Professor of Biomedical Engineering. Biomedical Engineering (1998 - 2004)
    • Columbia University , Associate Research Scientist. Department of Orthopaedic Surgery (1995 - 1998)
    • `Columbia University , Postdoctoral Research Scientist at the Orthopaedic Research Lab. Department of Orthopaedic Surgery (1994 - 1995)
    • Columbia University , Graduate Research Assistant at the Orthopaedic Research Lab. Orthopaedic Surgery (1988 - 1994)
    • Shanghai Jiao Tong University, Assistant Lecturer. Department of Engineering Mechanics (1986 - 1988)

PUBLICATIONS

  • Juried or Refereed Journal Articles or Exhibitions

    • Wang, Y., Barrera, C. M., Dauer, E. A., Gu, W., Andreopoulos, F. M., Huang, C. Y. (2017).Systematic characterization of porosity and mass transport and mechanical properties of porous polyurethane scaffolds. Journal of the Mechanical Behavior of Biomedical Materials, 65, 657-664.
    • Gao, X., Zhu, Q., Gu, W. (2016).An anisotropic multiphysics model for intervertebral disc. Journal of Applied Mechanics, 83(2), 8 pages. http://doi.org/10.1115/1.4031793.
    • Zhu, Q., Gao, X., Levene, H., Brown, M., Gu, W. (2016).Influences of Nutrition Supply and Pathways on the Degenerative Patterns in Human Intervertebral Disc. Spine, 41, 568-576. http://doi.org/10.1097/BRS.0000000000001292
    • Zhu, Q., Gao, X., Li, N., Gu, W., Eismont, F., Brown, M. D. (2016).Kinetics of Charged Antibiotic Penetration into Human Intervertebral Discs: A Numerical Study. Journal of Biomechanics, 49, 3079-3084. http://doi.org/10.1016/j.jbiomech.2016.07.012.
    • Gao, X., Zhu, Q., Gu, W. (2016).Prediction of Glycosaminoglycan Synthesis in Intervertebral Disc under Mechanical Loading. Journal of Biomechanics, 49, 2655-2661. http://doi.org/http://dx.doi.org/10.1016/j.jbiomech.2016.05.028.
    • Zhu, Q., Gao, X., Temple, H., Brown, M., Gu, W. (2016).Simulation of biological therapies for degenerated intervertebral discs. Journal of Orthopaedic Research, 34. http://doi.org/doi:10.1002/jor.23061
    • Gao, X., Zhu, Q., Gu, W. (2015).Analyzing the effects of mechanical and osmotic loading on glycosaminoglycan synthesis rate in cartilaginous tissues. Journal of Biomechanics, 48, 573-577.
    • Gao, X., Gu, W. (2014).A new constitutive model for hydration-dependent mechanical properties in biological soft tissues and hydrogels. Journal of Biomechanics, 47, 1396-3200. http://doi.org/10.1016/j.jbiomech.2014.06.012
    • Gu, W., Zhu, Q., Gao, X., Brown, M. M. (2014).Simulation of the progression of intervertebral disc degeneration due to decreased nutrition supply. Spine, 39, E1411-E1417. http://doi.org/10.1097/BRS.0000000000000560
    • Zhu, Q., Gao, X., Gu, W. (2014).Temporal changes of mechanical signals and extracellular composition in human intervertebral disc during degenerative progression. Journal of Biomechanics, 47, 3734-3743. http://doi.org/10.1016/j.jbiomech.2014.09.004
    • Wang, C., Gonzales, S. D., Leven, H., Gu, W., Huang, C. (2013).Energy Metabolism of Intervertebral Disc under Mechanical Loading. Journal of Orthopedic Research, 31, 1733-1738.
    • Zhu, Q., Jackson, A. R., Gu, W. (2012).Cell viability in intervertebral disc under various nutritional and dynamic loading conditions: 3D Finite element analysis. Journal of Biomechanics, 45, 2769-2777. http://doi.org/10.1016/j.jbiomech.2012.08.044
    • Jackson, A. R., Yuan, T., Huang, C., Bown, M. D., Gu, W. (2012).Nutrient Transport in Human Annulus Fibrosus is Affected by Compressive Strain and Anisotropy. Annals of Biomedical Engineering, 40, 2551-8. http://doi.org/10.1007/s10439-012-0606-4
    • Huang, C., Travascio, F., Gu, W. (2012).Quantitative Analysis of Exogenous IGF-1 Administration of Intervertebral Disc Through Intradiscal Injection. Journal of Biomechanics, 45, 1149-1155. http://doi.org/10.1016/j.jbiomech.2012.02.005
    • Gamez Sazo, R. E., Maenaka, K., Gu, W., Wood, P. M., Bunge, M. B. (2012).Fabrication of growth factor- and extracellular matrix-loaded, gelatin-based scaffolds and their biocompatibility with Schwann cells and dorsal root ganglia. Biomaterials, 33, 8529-39. http://doi.org/10.1016/j.biomaterials.2012.07.028.
    • Jackson, A. R., Huang, C., Brown, M. D., Gu, W. (2011).3D Finite Element Analysis of Nutrient Distributions and Cell Viability in The Intervertebral Disc: Effects of Deformation and Degeneration. Journal of Biomechanical Engineering, 133.
    • Salvatierra, J., Yuan, T., Fernando, H. N., Castillo, A., Gu, W., Cheung, H. S., Huang, C. (2011).Difference in Energy Metabolism of Annulus Fibrosus and Nucleus Pulposus Cells of The Intervertebral Disc. Cellular and Molecular Bioengineering, 4, 302-310.
    • Jackson, A. R., Huang, C., Gu, W. (2011).Effect of Endplate Calcification and Mechanical Loading on the Distribution of Glucose in Intervertebral Disc: A 3-D Finite Element Study. Computer Methods in Biomechanics and Biomedical Engineering, 14, 195-204.
    • Fernando, H. N., Czamanski, J., Yuan, T., Gu, W., Abdi, S., Huang, C. (2011).Mechanical Loading Affects the Energy Metabolism of Intervertebral Disc Cells. Journal of Orthopedic Research, 29, 1634-41.
    • Yuan, T., Huang, C., Gu, W. (2011).Novel Technique for Online Characterization of Cartilaginous Tissue Properties. Journal of Biomechanical Engineering, 133, 94504.
    • Travascio, F., Gu, W. (2011).Simultaneous measurement of anisotropic solute diffusivity and binding reaction rates in biological tissues by FRAP. Annals of Biomedical Engineering, 39, 53-65. http://doi.org/10.1007/s10439-010-0138-8
    • Jackson, A. R., Yuan, T., Huang, C., Gu, W. (2009).A conductivity approach to measuring fixed charge density in intervertebral disc tissue. Annals of Biomedical Engineering, 37, 2566-2573. http://doi.org/10.1007/s10439-009-9792-0
    • Travascio, F., Zhao, W. Z., Gu, W. (2009).Characterization of anisotropic diffusion tensor of solute in tissue by video-FRAP imaging technique. Annals of Biomedical Engineering, 37, 813-823.
    • Travascio, F., Jackson, A. R., Brown, M. D., Gu, W. (2009).Relationship between solute transport properties and tissue morphology in human annulus fibrosus. Journal of Orthopaedic Research, 27, 1625-1630. http://doi.org/10.1002/jor.20927
    • Jackson, A. R., Gu, W. (2009).Transport properties of cartilaginous tissues. Current Rheumatology Review, 5, 40-50.
    • Yuan, T., Jackson, A. R., Huang, C., Gu, W. (2009).Strain-dependent diffusion coefficient of oxygen in bovine annulus fibrosus. Journal of Biomechanical Engineering, 131, 074503/1-4.
    • Flagler, D., Huang, C., Yuan, T., Lu, Z., Cheung, H. S., Gu, W. (2009).Intracellular Flow Cytometric Measurement of Extracellular Matrix Components in Porcine Intervertebral Disc Cells. Cellular and Molecular Bioengineering, 2, 264-273.
    • Jackson, A. R., Travascio, F., Gu, W. (2009).Effect of mechanical loading on electrical conductivity in human intervertebral disc. Journal of Biomechanical Engineering, 131, 054505/1-5.
    • Jackson, A. R., Yuan, T., Huang, C., Travascio, F., Gu, W. (2008).Effect of compression and anisotropy on the diffusion of glucose in annulus fibrosus. Spine, 33, 1-7.
    • Huang, C., Gu, W. (2008).Effects of mechanical compression on metabolism and distributions of oxygen and lactate in intervertebral disc. Journal of Biomechanics, 41, 1184-1196.
    • Huang, C., Gu, W. (2008).Effects of mechanical compression on metabolism and distributions of oxygen and lactate in intervertebral disc. Journal of Biomechanics, 41, 1184-1196.
    • Travascio, F., Gu, W. (2007).Anisotropic diffusive transport in annulus fibrosus: Experimental determination of the diffusion tensor by FRAP technique. Annals of Biomedical Engineering, 35, 1739-1748.
    • Yao, H., Gu, W. (2007).Convection and diffusion of solute in charged hydrated soft tissues: a mixture theory approach. Journal of Biomechanics and Modeling in Mechanobiology, 6, 63-72.
    • Huang, C., Yuan, T., Jackson, A. R., Huzbun, L., Fraker, C., Gu, W. (2007).Effects of low glucose concentration on oxygen consumption rates of intervertebral disc cells. Spine, 32, 2063-2069.
    • Huang, C. Y., Gu, W. (2007).Effects of tension-compression nonlinearity on solute transport in charged hydrated fibrous tissues under dynamic compression. Journal of Biomechanical Engineering, 129, 423-429.
    • Fraker, C. A., Alvarez, S., Papadopoulos, P., Giraldo, J., Gu, W., Ricordi, C., Inverardi, L., Dominguez-Bendala, J. (2007).Enhanced oxygenation promotes beta cell differentiation in vitro. Stem Cells, 25, 3155-3164.
    • Yao, H., Gu, W. (2007).Three-dimensional inhomogeneous triphasic finite element analysis of physical signals and solute transport in human intervertebral disc under axial compression. Journal of Biomechanics, 40, 2071-2077.
    • Jackson, A. R., Yao, H., Brown, M., Gu, W. (2006).Anisotropic ion diffusivity in intervertebral disc: an electrical conductivity approach. Spine, 31, 2783-2789.
    • Yao, H., Gu, W. (2006).Physical signals and solute transport in human intervertebral disc during compressive stress relaxation: 3D finite element analysis. Biorheology, 43, 323-335.
    • Gu, W., Sun, D. N., Lai, W. M., Mow, V. C. (2004).Analysis of the dynamic permeation experiment with implication to cartilaginous tissue engineering. J Biomechanical Engineering, 26, 485-491.
    • Gu, W., Yao, H., Vega, A., Flagler, D. (2004).Diffusivity of ions in agarose gels and intervertebral disc: Effect of porosity. Annals of Biomedical Engineering, 32, 1710-1717.
    • Yao, H., Gu, W. (2004).Physical signals and solute transport in cartilage under dynamic unconfined compression: Finite element analysis. Annals of Biomedical Engineering, 32, 380-390.
    • Gu, W., Yao, H. (2003).Effects of hydration and fixed charge density on fluid transport in charged hydrated soft tissues. Annals of Biomedical Engineering, 31, 1162-1170.
    • Gu, W., Yao, H., Huang, C., Cheung, H. S. (2003).New insight into deformation-dependent hydraulic permeability of gels and cartilage, and dynamic behavior of agarose gels in confined compression. J Biomechanics, 36, 593-598.
    • Gu, W., Justiz, M. A. (2002).Apparatus for measuring the swelling dependent electrical conductivity of charged hydrated soft tissues. J Biomechanical Engineering, 124, 790-793.
    • Yao, H. .., Justiz, M. A., Flagler, D., Gu, W. (2002).Effects of Swelling Pressure and Hydraulic Permeability on Dynamic Compressive Behavior of Lumbar Annulus Fibrosus. Annals of Biomedical Engineering, 30, 1234-1241.
    • Gu, W., Justiz, M. A., Yao, H. (2002).Electrical conductivity of lumbar annulus fibrosis: Effects of porosity and fixed charge density. Spine, 27, 2390-2395.
    • Gu, W., DiDonato, D., Reuben, P., Howell, D. S., Cheung, H. S. (2000).Dynamic mechanical loading increases metalloproteinase levels in articular cartilage. Trans Orthop Res Soc, 25, 650.
    • Sun, D. N., Gu, W., Guo, X. E., Lai, W. M., Mow, V. C. (1999).A mixed finite element formulation of triphasic mechano-electrochemical theory for charged, hydrated biological soft tissues. International Journal for Numerical Methods in Engineering, 45, 1375-1420.
    • Gu, W., Mao, X. G., Rawlins, B. A., Foster, R. J., Iatridis, J. C., Sun, D. N., Weidenbaum, M., Mow, V. C. (1999).Streaming potential of human lumbar anulus fibrosus is anisotropic and affected by disc degeneration. J Biomechanics, 32, 1183-1189.
    • Gu, W., Mao, X. G., Foster, R. J., Weidenbaum, M., Mow, V. C., Rawlins, B. A. (1999).The anisotropic hydraulic permeability of human lumbar anulus fibrosus: Influence of age, degeneration, direction, and water content. Spine, 24, 2449-2455.
    • Gu, W., Lai, W. M., Mow, V. C. (1999).Transport of multi-electrolytes in charged hydrated biological soft tissues. Transport in Porous Media, 34, 143-157.
    • Gu, W., Lai, W. M., Mow, V. C. (1998).A mixture theory for charged hydrated soft tissues containing multi-electrolytes: Passive transport and swelling behaviors. J Biomechanical Engineering, 120, 169-180.
    • Mow, V. C., Ateshian, G. A., Lai, W. M., Gu, W. (1998).Effects of fixed charge density on the stress-relaxation behavior of hydrated soft tissues in a confined compression problem. International Journal of Solids and Structures, 35, 4945-4962.
    • Lai, W. M., Gu, W., Mow, V. C. (1998).On the conditional equivalence of chemical loading and mechanical loading on articular cartilage. J Biomechanics, 31, 1181-1189.
    • Gu, W., Lai, W. M., Mow, V. C. (1997).A triphasic analysis of negative osmotic flow through charged-hydrated soft tissues. J Biomechanics, 30, 71-78.
    • Gu, W., Lai, W. M., Mow, V. C. (1993).Transport of fluid and ions through a porous-permeable charged-hydrated tissue, and streaming potential data on normal bovine articular cartilage. J Biomechanics, 30, 709-723.
  • Book Chapters

    • Mow, V. C., Gu, W., Chen, F. H., (2005). Structure and Function of Articular Cartilage and Meniscus. Basic Orthopaedic Biomechanics & Mechano-Biology (pp. 181-258). Lippincott Williams and Wilkins.
    • Setton, L. A., Gu, W., Lai, W. M., Mow, V. C., (1995). Predictions of the swelling-induced pre-stress in articular cartilage. Mechanics of Poroelastic Media (pp. 299-322). Kluwer Academic Publishers.
    • Lai, W. M., Gu, W., Setton, L. A., Mow, V. C., Swelling properties of articular cartilage. Structure and Function of Articular Cartilage (pp. ). CRC Press.

 

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