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Herman Cheung

Photo of Herman Cheung

Herman Cheung

James L. Knight Professor | College of Engineering | Biomedical Engineering Department
Work Phone: (305) 284-4466


Resume
Intranet

 

HIGHER EDUCATION

    • University of S. California, Los Angeles, CA, Ph.D. in Molecular Biology. (1974)
    • Loyola Marymount University , Los Angeles, CA, B.S. in Biological Sciences. (1968)

EXPERIENCE

    • Chinese University of Hong Kong, Adjunct Professor. Ophthalmology and Visual Sciences (2010 - Present)
    • University of Hong Kong, Visiting Research Professor. (2010 - Present)
    • Miami VA Medical Center, Chair. (2009 - Present)
    • Scientific Review Committee of the Miami VA Medical Center, Chairman. (2009 - Present)
    • Interdisciplinary Stem Cell Institute, University of Miami, Founding Member and Board Member. (2008 - Present)
    • Member of the Rank & Tenure Committee, . College of Engineering, University of Miami (2008 - Present)
    • College of Engineering Tenure and Promotion Review Board, UM, Member. (2007 - Present)
    • Walter H. Coulter Center of Translation Research, University of Miami , Founding member and Internal Board Member. (2004 - Present)
    • Miami VA Medical Center, Senior VA Medical Research Career Scientist (Grade 15). School of Medicine (2004 - Present)
    • UM Research Council, Member . (2003 - Present)
    • University of Miami, Professor Biomedical Engineering (Tenure). Biomedical Engineering (2003 - Present)
    • Miami VA Medical Center, Space Subcomittee. (2003 - Present)
    • “Cellular Therapies and Tissue Engineering Initiative” at the University of Miami, Co-Director. (2001 - Present)
    • Graduate Faculty, Member. (2001 - Present)
    • Advisory Committee for General Clinical Research Center, University of Miami, Member. (2000 - Present)
    • University of Miami, Professor of Orthopaedic Surgery & Rehabilitation. (1997 - Present)
    • University of Miami, Professor of Medicine. (1996 - Present)
    • Miami VA Medical Center, Research Biologist. (1996 - Present)
    • School of Business Administration and College of Engineering UNDERGRADUATE DEGREE CEREMONY, Grand Marshal. (2015)
    • Dean of Engineering Search Committee , Member. (2014 - 2015)
    • Chinese University of Hong Kong, and Shantou University School of Medicine, Eye Hospital. (2014)
    • Academic Board, Member. (2011 - 2013)
    • University of Miami, Faculty Senator. (2009 - 2013)
    • Shantou University Medical College, Honorary Visiting Professor. (2010)
    • Chinese University of Hong Kong, Adjunct Professor. (2009)
    • Chinese University of Hong Kong and Shantou University School of Medicine, Visiting Professor. (2008)
    • Dean of Engineering Search Committee , Member. (2007)
    • College of Engineering Research Council, Member . (2001 - 2006)
    • Miami VA Medical Center, VA Research Career Scientist (Grade 14). (1999 - 2004)
    • Search Committee for Chief of Rheumatology, University of Miami, Member. (2002)
    • Search Committee for Associate Chief of Staff, Miami VA Medical Center, Chairman. (2001)
    • University of Miami School of Medicine, Member of Graduate Faculty. (2001)
    • University of Miami School of Medicine, Site Director, National Science Foundation Industry/University Center of Biosurfaces. (1998 - 2001)
    • New York State College of Ceramics, Site Evaluator for the graduate program. (1999)
    • University of Miami School of Medicine, Professor of Biomedical Engineering. Biomedical Engineering (1998)
    • Medical College of Wisconsin, Professor of Medicine, Biochemistry, and Orthopaedic Surgery (tenured). (1986 - 1996)
    • Vanderbilt School of Medicine, Visiting Professor,Department of Cell Biology. Department of Cell Biology (1987)
    • Medical College of Wisconsin, Associate Professor of Medicine, Biochemistry, and Orthopaedic Surgery. (1981 - 1986)
    • Medical College of Wisconsin, Assistant Professor of Medicine, Biochemistry, and Orthopaedic Surgery. (1977 - 1981)
    • University of Southern California, NIH Postdoctoral Fellow (Biochemistry). (1974 - 1977)

PUBLICATIONS

  • Juried or Refereed Journal Articles or Exhibitions

    • Pelaez, D., Torres, Z. A., Ng, T. K., Choy, K. W., Pang, C. P., Cheung, H. S. (2016).Cardiomyogenesis of periodontal ligament-derived stem cells by dynamic tensile strain. Cell Tissue Res.. http://doi.org/10.1007 /s00441-016-2503-x
    • Kittivarakarn, P., Penna, M., Acosta, Z., Pelaez, D., Montero, R., Andreopoulos, F. M., Cheung, H. S. (2016).Cardiomyotic induction and proliferation of dental stem cells on electrospun scaffolds. AIMS Bioengineering, 3(2), 139-155. http://doi.org/10.3934/bioeng.2016.2.139
    • Carballosa, C. M., Greenberg, J. M., Cheung, H. S. (2016).Expression and function of nicotinic acetylcholine receptors in stem cells. AIMS Bioengineering, 3, 3, 245-263. http://doi.org/10.3934.2016.3.245
    • Pelaez, D., Michel, J. H., Cheung, H. S. (2016).Growth on elastic silicone substrate elicits a partial myogenic response in periodontal ligament derived stem cells. AIMS Bioengineering, 3, 4, 515-526. http://doi.org/10.3934/bioeng.2016.4.515
    • Gan, J., Ke, X., Jiang, J., Dong, H., Yao, Z., Lin, Y., Lin, W., Wu, X., Yan, S., Zhuang, Y., Chu, W. K., Cai, R., Zhang, X., Cheung, H. S. (2016).Growth hormone-releasing hormone receptor antagonists inhibit human gastric cancer through downregulation of PAK1–STAT3/ NF-κB signaling. Proc Natl Acad Sci U S A. http://doi.org/201618582
    • Chu, W. K., Law, K. S., Chan, S. O., Yam, J. C., Chen, L. J., Zhang, H., Cheung, H. S., Block, N. L., Schally, A. V., Pang, C. P. (2016).Antagonists of growth hormone-releasing hormone receptor induce apoptosis specifically in retinoblastoma cells. Proc Natl Acad Sci U S A. http://doi.org/201617427
    • Ng, T. K., Huang, L., Cao, D., Yip, Y. W., Tsang, W. M., Yam, G. H., Pang, C. P., Cheung, H. S. (2015).Cigarette smoking hinders human periodontal ligament-derived stem cells regenerative potential.. Scientific Reports 5 : 7828. http://doi.org/10.1038/srep07828
    • Michel, J., Penna, J., Kochen, J., Cheung, H. S. (2015).Recent Advances in Hydroxyapatite Scaffolds containing Mesenchymal Stem Cells. Stem Cell International, 2015, 1-13.
    • Ng, T. K., Yung, J. Y., Choy, K. W., Cao, D., Leung, C. S., Cheung, H. S., Pang, C. P. (2015).Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature. Scientific Reports. 5:16429I. http://doi.org/10.1038/srep16429
    • Ng, T. Y., Huang, L., Cao, D., Yip, Y. W., Tsang, W. M., Yam, G. H., Pang, C. P., Cheung, H. S. (2015).Cigarette smoking hinders human periodontal ligament-derived stem cells regenerative potential. Scientific Report, 5, . 5 : 7828-7833.
    • Qin, Y. J., Chan, S. O., Chong, K. K., Li, B. F., Ng, T. K., Chen, H., Zhang, M., Cheung, H. S., Schally, A. V., Pang, C. P. (2014).Antagonist of GH-releasing hormone receptor alleviates experimental ocular inflammation.. PNAS, 111, 18303-18308.
    • Gonzales, S., Wang, C., Levine, H., Cheung, H. S., Huang, C. C. (2014).ATP promotes extracellular matrix biosynthesis of intervertebral disc cells. Cell Tissue Res.. http://doi.org/10.1007/s00441-014-2042-2
    • Fortino, V. R., Pawley, D., Ecker, N., Acosta, Z., Cheung, H. S. (2014).Neurogenesis from stem cells. Recent Patents on Regenerativer Medicine, 4, 20-Jan.
    • Fortino, V. R., Chen, R. S., Pelaez, D., Cheung, H. S. (2014).Neurogenesis of Neural Crest-Derived Periodontal Ligament Stem Cells by Defined Media. J Cell Physiol, 229(4), 479-88.
    • Fortino, V. R., Pawley, D., Ecker, N., Acosta, Z., Kochen, J. A., Cheung, H. S. (2014).Neurogenesis of Stem Cells. Journal of Recent Patents in Regenerative Medicine, 4, 16-33.
    • Qin, Y. J., Chan, S. O., Chong, K. K., Li, B. F., Ng, T. K., Wong, Y., Chen, H. Y., Zhang, M. Z., Block, N. L., Cheung, H. S., Schally, A. V., Pang, C. P. (2014).An antagonist of GH-releasing hormone receptors alleviates experimental ocular inflammation. PNAS USA. http://doi.org/10.1073/pnas.1421815112
    • Fortino, V. R., Pawley, D., Ecker, N., Acosta, Z., Kochen, K. A., Cheung, H. S. (2014).Neurogenesis from Stem Cells.. Journal of Recent Patents in Regenerative Medicine., 4, 16-33.
    • Carballosa, C. M., Fernandez-Fidalgo, D. J., Cheung, H. S. (2014)." Nicotines Influence on Musculoskeletal Healing: A Review Featuring nAChRs and miRNA. GJMR-H, 14, Issue 1 Version 1.0.
    • Carballosa, C. M., Fernandez-Fidalgo, D. J., Cheung, H. S. (2014).Nicotine Influence on Musculoskeletal Healing: A Review Featuring nAChRs and miRNA. GJMR-H, 14 .
    • Ng, T. K., Fortino, V. R., Pelaez, D., Cheung, H. S. (2014).Progress of mesenchymal stem cell therapy for neural and retinal diseases. World journal of Stem Cells, 6 (2), 111-119. http://doi.org/10.4252/ wjsc.v6.i2.111
    • Huang, L., Liang, J., Tsang, W., Teng, Y., Yao, X., Zang, Y., Cheung, H. S., Pang, C. P., Yam, H. F. (2013).Differentiation of retinal progenitor and photoreceptors from human adult periodontal ligament.. IOVS, 54, 3965-3974.
    • Pelaez, D., Cheung, H. S. (2013).Dynamic Tensile Strain Induces Cardiomyogenesis of Periodontal Ligament-Derived Stem Cells. Differentiation.
    • Pelaez, D., Huang, C. Y., Cheung, H. S. (2013).Isolation of Pluripotent Neural Crest Remnant Stem Cells from Adult Human Tissues by Connexin 43 Enrichment. Stem Cell & Development, 22(21), 2906-2914.
    • Ng, T. K., Carballosa, C. M., Pelaez, D., Wong, H. K., Choy, K. W., Pang, C. P., Cheung, H. S. (2013).Nicotine alters microRNA expression and hinders human adult stem cell regenerative potentials. Stem Cell & Development, 22, 781-790.
    • Ng, N. T., Lam, D., Cheung, H. S. (2013).Prospect of stem cells for retinal diseases. Asia-Pacific Journal of Ophthalmology, 2(1), 57-63.
    • Ruiz, J. P., Ecker, N., Pawley, D., Cheung, H. S. (2013).Recent advances in bioreactors in tissue engineering and regenerative medicine. Current Tissue Engineering, 2 (2), 133-144.
    • Fortino, V. R., Pelaez, D., Cheung, H. S. (2013).Stem Cell Therapies for Neuropathic Pain. Stem Cells Translational Medicine, 2(5)2013, 394-399.
    • Martinez, C., Sasmita, R., Van Gulden, S., Pelaez, A., Alfonso, A., Kos, L. L., Cheung, H. S., Ramaswamy, S. (2013).Periodontal Ligament Cells Cultured under Steady Flow Environments Demonstrate Potential for Use in Heart Valve Tissue Engineering. Tissue Engineering, Part A 19 (3&4), 458-466.
    • Isobe, I. S., Cheung, H. S., Wu, J. I. (2012).Editorial. Toward Personalized Cell Therapies by Using Stem Cells, 2, 2-Jan.
    • Cheung, H. S. (2012).Editorial: Current Tissue Engineering. 1:1.
    • Isobe, K. I., Cheung, H. S., Wu, J. I. (2012). Editorial: Toward Personalized Cell Therapies by Using Stem Cells. Biomed & Biotech., 2:1.
    • Pelaez, D., Arita, N., Cheung, H. S. (2012).Extracellular Signal-Regulated Kinase (ERK) Dictates Osteogenic and/or Chondrogenic Lineage Commitment of Mesenchymal Stem Cells under Dynamic Compression. Biochem. Biophys. Res. Comm, 417, 1286-1291.
    • Greenberg, J. M., Fortino, V., Pelaez, D., Cheung, H. S. (2012).Stem cell-based tissue engineering and regenerative medicine. Current Tissue Engineering, 1, 75-82.
    • Ruiz, R. P., Pelaez, D., Diaz, J., Ziebarth, J. M., Cheung, H. S. (2012).The Effect of Nicotine on the physical Properties of Mesenchymal Stem Cells.. Cell Health and Cytoskeleton, 4, :29-35,.
    • Arita, N., Pelaez, D., Cheung, H. S. (2011).Activation of the Extracellular Signal-Regulated Kinases 1 and 2 (ERK1/2) is needed for the TGF-Induced Chondrogenic and Osteogenic Differentiation of Mesenchymal Stem Cells. Biochem. Biophys. Res. Comm..
    • Salvatierra, J. C., Yuan, T., Fernando, H. N., Castillo, A., Gu, W. Y., Cheung, H. S., Huang, C. (2011).Difference in Energy Metabolism of Annulus Fibrosus and Nucleus Pulposus Cells of The Intervertebral Disc. Cellular and Molecular Bioengineering. http://doi.org/4:302-310
    • Isobe, K. I., Cheung, H. S., Wu, J. I. (2011).Editorial. Toward Personalized Cell Therapies by Using Stem Cells, 2, 2-Jan.
    • Isobe, K. I., Cheung, H. S., Wu, J. I. (2011).Editorial: Toward Personalized Cell Therapies by Using Stem Cells. J. Biomed & Biotech, 1:1-2.
    • Fritz, J. R., Pelaez, D., Cheung, H. S. (2009).Current challenges in cartilage tissue engineering: a review of current cellular-based therapies. Current Rheumatology Review, 5(1), 14-Aug.
    • Pelaez, D., Huang, C. Y., Cheung, H. S. (2009).Dynamic compression maintains viability and induces chondrogenesis of human MSC in fibrin Gel.. Stem Cell & Development, 18(1), 93-102.
    • Cheung, H. S. (2009).Editorial: Stem Cells, Osteoarthritis and Cartilage Repair. Current Rheumatology Reviews, 5(1), 2-Jan.
    • Cheung, H. S., McCarthy, G. M. (2009).Hydroxyapatite crystal deposition is intimately involved in the pathogenesis and progression of human osteoarthritis. Curr. Rheumatol Rep., 11(2), 141-147.
    • Flagler, D. J., Huang, C. Y., Yuan, T. Y., Li, X., Laquian, L., Cheung, H. S., Gu, W. Y. (2009).Intracellular flow cytometric measurement of extracellular matrix components in porcine intervertebral disc cells. Cellular and Molecular Bioengineering, 2, 264-273.
    • Huang, C. Y., Pelaez, D., Dominguez-Bendala, D., Garcia-Godoy, F., Cheung, H. S. (2009).Plasticity of stem cells derived from adult periodontal ligament. Regenerative Medicine, 4(6), 809-821.
    • Bahuleyan, B., Cheung, H. S., Huang, C. Y. (2009).Role of mechanical force in stem cell-based therapy for cartilage repair. Current Rheumatology Reviews, 5(1), 34-36.
    • Howard, G. A., Schiller, P. C., D‰ÛªIppolito, G., Cheung, H. S., Troen, B. R., Roos, B. A. (2007).Adult stem cells and regenerative medicine at the Miami GRECC.. Federal Practitioner, 24, 30-37.
    • Major, M. L., Cheung, H. S., Misra, R. P. (2007).Basic calcium phosphate crystals activate c-fos expression through a ras-dependent signaling mechanism. Biochem. Biophys. Res. Comm., 335, 654-660.
    • Huang, C. Y., Cheung, H. S., Dietzer, M. A. (2007).Effects of fibrinolytic inhibitors on chondrogenesis of bone-marrow derived mesenchymal stem cells in fibrin gels.. Biomech. Model Mechanobiol., 6, 11-May.
    • Sun, Y., Gruber, H. E., Firestein, G. S., Boyle, D. L., Cheung, H. S. (2007).Long term culture of telomerase transduced rheumatoid arthritis fibroblast-like synoviocyte display a distinct gene expression pattern.. J Rheum, 34, 1959-1970.
    • Wu, J. Y., Lu, H., Graham, D. Y., Sun, Y., Cheung, H. S., Yamaoka, Y. (2006).Balance between Polyoma Enhancing Activator-3 and Activator Protein-1 Regulates Helicobacter pylori-stimulated Matrix Metalloproteinase-1 Expression. Cancer Res., 66(10), 5111-20.
    • Cheung, H. S. (2006).Crystal/Cell Interactions in Osteoarthritis. Curr. Opin. in Orthopededics, 17(5), 424-428.
    • Waveren, C. V., Sun, Y., Heung, H. S., Moraes, C. T., Cheung, H. S. (2006).Oxidative phosphorylation dysfunction modulates transcription of extracellular matrix-remodeling genes.. Carcinogenesis, 27(3), 409-418.
    • Cheung, H. S., Sallis, J. D., Demadis, K. D., Wierzicki, A. (2006).Phosphocitrate blocks calcification-induced articular joint degeneration.. Arthritis & Rheum., 54(8), 2452-2461.
    • Sallis, J. D., Demadis, K. D., Cheung, H. S. (2006).Phosphocitrate, a Potential Therapeutic Agent for Calcium Crystal Deposition Diseases,. Curr. Rheum. Reviews, 2(1), 95-99.
    • Reuben, P. M., Cheung, H. S. (2006).Regulation of matrix metalloproteinase (MMP) gene expression by protein kinases.. Frontiers in Biosciences., 1(11), 199-215.
    • Zeng, X. R., Sun, Y., Wenger, L., Cheung, H. S. (2005).Basic Calcium Phosphate Crystals Induced Egr-1 Expression Stimulates Mitogenesis in Human Fibroblasts. Biochem. Biophys. Res. Comm, 330, 658-664.
    • Cheung, H. S. (2005).Biologic effects of calcium-containing crystals.. Curr. Opinion Rheum., 17, 336-340.
    • Sun, Y., Reuben, P. M., Wenger, L., Sallis, J., Demadis, K. D., Cheung, H. S. (2005).Inhibition of calcium phosphate-DNA co-precipitates-induced cell death by phosphocitrate. Frontiers in Biosciences, 10, 803-808.
    • Dalal, P., Zannotti, K., Wiezbicki, A., Madura, J. D., Cheung, H. S. (2005).Molecular dynamics simulation studies of the effect of phosphocitrate on crystal-induced membranolysis,. Biophysical J., 89, 7-Jan.
    • Cheung, H. S. (2005).Role of calcium-containing crystals in osteoarthritis. Frontiers in Biosciences, 10, 803-808.
    • Huang, C. Y., Cheung, H. S. (2005).Temporal Expression Patterns of Early Responsive Genes in Rabbit Bone-Marrow Derived Mesenchymal Stem Cells Under Cyclic Compressive Loading. Stem Cells, 23(8), 1113-21.
    • Reuben, P. M., Sun, Y., Cheung, H. S. (2004).Basic calcium phosphate crystals activate P44/42 MAPK signal transduction pathway via protein kinase C ? in human fibroblasts.. J. Biol. Chem., 279, 35719-35725.
    • Huang, C. Y., Reuben, P. M., D‰ÛªIppolito, G., Schiller, P., Cheung, H. S. (2004).Chondrogenesis of human bone marrow derived mesenchymal stem cells in agarose culture. Anatomical Record, 278A, 428-436.
    • Huang, C. Y., Hagar, K., Frost, L., Sun, Y., Cheung, H. S. (2004).Effects of Cyclic Compressive Loading on Chondrogenesis of Human and Rabbit Bone Marrow-Derived Mesenchymal Stem Cells.. Stem Cells, 22, 313-323.
    • Sun, Y., Zeng, X. R., Wenger, W., Firestein, G. S., Cheung, H. S. (2004).P53 down-regulate matrix metalloproteinase-1 by targeting the communications between AP-1 and basal transcription complex. J. Cell Biochem., 92, 258-269.
    • Sun, Y., Firestein, G. S., Wenger, L., Cheung, H. S., Huang, C. Y. (2004).Telomerase immortalized osteoarthritic fibroblast-like synoviocytes line: A potential valuable tool for research.. Biochem. Biophys. Res. Comm., 323, 1287-1292.
    • Rogachefsky, R. A., Altman, R. D., Markov, M. S., Cheung, H. S. (2004).Use of a permanent magnetic mattress to inhibit the development of canine osteoarthritis. Bioelectromagnetics, 25, 260-270.
    • Sun, Y., Zeng, X. R., Wenger, L., Cheung, H. S. (2003).Basic calcium phosphate crystals stimulate the endocytotic activities of cells?inhibition by anti-calcification agents. Biochem. Biophys. Res. Comm., 312, 1053-1059.
    • Zeng, X. R., Sun, Y., Wenger, L., Cheung, H. S. (2003).Induction of early growth response gene EGR2 by BCP crystals through calcium-dependent PKC-independent p42/44 MAPK pathway. Cell, Tissue and Organ, 174, 63-72.
    • Sallis, J. D., Cheung, H. S. (2003).Inhibitors of articular calcium crystals. Curr. Opinion Rheum., 15, 321-325.
    • Wiezbicki, A., Dalal, P., Madura, J., Cheung, H. S. (2003).Molecular dynamics simulation of crystal induced membranolysis. J. Phys. Chem. B., 107(44), 12346-12351.
    • Gu, W. Y., Huang, C. Y., Cheung, H. S. (2003).New insight into deformation-dependent hydraulic permeability and dynamic compressive behavior of agarose gels. J. Biomechanics, 30, 593-598.
    • Narmoneva, D. A., Cheung, H. S., Wang, J. Y., Howell, D. S., Setton, L. A. (2002).Altered swelling behavior of femoral cartilage following joint immobilization in a canine model.. J. Orthopaedic Research., 83-91.
    • Sun, Y., Wenger, L., Brinckerhoff, C. E., Misra, R., Cheung, H. S. (2002).BCP crystals induced matrix metalloproteinase-1 through RAS/MEK1/SRF/c-fos/AP-1/MMP-1. Pathway: Involvement of transcription factor binding sites: PEA-3 and AP-1.. J. Biol. Chem, 1544-1552.
    • Reuben, P. M., Brogley, M. A., Sun, Y., Cheung, H. S. (2002).Molecular Mechanism of the Induction of Metalloproteinases 1 and 3 in Human Fibroblasts by Basic Calcium Phosphate Crystals. Role of calcium-dependent protein kinase C-?.. J. Biol. Chem., 277, 15190-15198.
    • Sun, Y., Cheung, H. S. (2002).P53, a therapeutic target for rheumatoid Arthritis.. Seminar Arthritis Rheum., 299-310.
    • Fahmi, H., Di Battista, J. A., Pelletier, J. P., Cheung, H. S., Fernandes, J. C., Martel-Pelletier, J. (2002).Peroxisome proliferator-activated gamma activators inhibit MMP-1 production in human synovial fibroblasts. A new possible role in synovial fibroblasts function. OA & Cartilage., 10, 100-108.
    • LeRoux, M. A., Cheung, H. S., Bau, J. L., Wang, J. Y., Howell, D. S., Setton, L. A. (2001).. Altered mechanics and histomorphometry of canine tibial cartilage following joint immobilization.. OA & Cartilage, 633-640.
    • McCarthy, G. M., Westfall, P. R., Masuda, I., Christopherson, P. A., Cheung, H. S., Mitchell, P. G. (2001).Basic calcium phosphate crystals activate human osteoarthritis synovial fibroblasts and induce matrix metalloproteinase-13 (collagenase-3) in adult porcine articular chondrocytes.. Ann Rheum. Dis., 399-406.
    • Bai, G., Howell, D. S., Roos, B. A., Howard, G. A., Cheung, H. S. (2001).BCP Crystals Upregulate Metalloproteinases and downregulate Tissue Inhibitor of metalloproteinase in human fibroblasts.. Osteoarthritis & Cart, 416-422.
    • Reuben, P. M., Wenger, L., Cruz, M., Cheung, H. S. (2001).Induction of metalloproteinase-8 in human fibroblasts by basic calcium phosphate crystals: Effect of phosphocitrate.. Conn. Tissue Res., 12-Jan.
    • Cheung, H. S. (2001).Phosphocitrate as a potential therapeutic strategy for crystal deposition disease. Current Rheumatology Reports, 24-28.
    • Cheung, H. S. (2000).Calcium crystal effects on the cells of the joint: Implications for pathogenesis of the disease.. Current Opinion in Rheumatology, 223-227.
    • Wambach, B. A., Cheung, H. S., Josephson, G. D. (2000).Cartilage tissue engineering using thyroid chondrocytes on type 1 collagen matrix.. Larynoscope., 2008-2011.
    • Wierzbicki, A., Cheung, H. S. (2000).Molecular modeling of inhibition of hydroxyapatite crystal by phosphocitrate.. J. Molecular Structure (Theochem), 73-82.
    • Sun, Y., Cheung, J. M., Martel-Pelletier, J., Pelletier, J. P., Wenger, L., Altman, R. D., Howell, D. S., Cheung, H. S. (2000).Wild type and mutant P53 differentially regulate the gene expression of human collagenase-3 (hMMP-13).. J. Bio. Chem., 11327-11332.
    • Brogley, M. A., Cruz, M., Cheung, H. S. (1999).Basic calcium phosphate crystal induction of collagenase-1 and stromelysin expression is dependent on a p42/44 mitogen-activated protein kinase signal transduction pathway.. J. Cell. Physiol., 215-224.
    • Ryan, L. M., Cheung, H. S., LeGeros, R. Z., Kurup, I. V., Toth, J., Westfall, P. R., McCarthy, G. M. (1999).Cellular responses to Whitlockite. Calcif. Tissue Int., 374-377.
    • Sun, Y., Wenger, L., Brinckerhoff, C. E., Cheung, H. S. (1999).Human metalloproteinase-1 (collagenase-1) is a tumor suppressor protein p53 target gene.. NY Acad. Science., 638-641.
    • Sun, Y., Wenger, L., Brinckerhoff, C. E., Cheung, H. S. (1999).P53 down-regulates human metalloproteinase-1 (collagenase-1) gene expression.. J. Biol. Chem, 11535-11540.
    • Cheung, H. S., Ryan, L. M. (1999).Phosphocitrate blocks nitric oxide-induced calcification. OA & Cartilage,, 409-412.
    • Cheung, H. S. (1999).The role of crystals in articular tissue degeneration. Current Rheumatology Reports, 128-131.
    • Ryan, L. M., Kurup, I. V., Cheung, H. S. (1999).Transduction mechanisms of chondrocyte inorganic pyrophosphate elaboration.. Arthritis & Rheum., 555-560.
    • McCarthy, G. M., Cheung, H. S., Abel, S. M., Ryan, L. M. (1998).Basic calcium crystal-induced collagenase production: role of intracellular crystal dissolution.. Osteoarthritis & Cartilage, 205-213.
    • Halverson, P. B., Cheung, H. S., Greene, A. (1998).Intracellular calcium responses to BCP crystals in fibroblasts.. Osteoarthritis & Cartilage, 324-329.
    • McCarthy, G. M., Augustine, J. A., Balwin, A. S., Christopherson, P. A., Cheung, H. S., Westfall, P. R., Scheinman, R. I. (1998).Molecular mechanism of BCP crystal-induced activation of human fibroblasts. Role of nuclear factor ?B, activator protein 1 and protein kinase C.. J. Biol. Chem, 35161-35169.
    • Wierzbicki, A., Cheung, H. S. (1998).Molecular modeling aspects of inhibition of crystals of calcium pyrophosphate dihydrate by phosphocitrate.. J. Molecular Structure, THEOCHEM, 287-297.
    • Cheung, H. S., Devine, T., Hubbard, H. (1997).Calcium Phosphate particle induction of metalloproteinase: effect of particle sizes.. Osteoarthritis & Cartilage, 145-151.
    • Nair, D., Misra, R. P., Sallis, J. D., Cheung, H. S. (1997).Phosphocitrate inhibits a basic calcium phosphate and calcium pyrophosphate dihydrate crystal-induced mitogen-activated protein kinase cascade signal transduction pathway.. J. Biol. Chem, 18920-18925.
    • Cheung, H. S., Kurup, I., Sallis, J. D., Ryan, L. M. (1996).Inhibition of CPPD crystal formation in articular cartilage vesicles and cartilage by phosphocitrate.. J. Biol. Chem, 28082-28085.
    • Cheung, H. S., Sallis, J. D., Struve, J. A. (1996).Specific inhibition of basic calcium phosphate and calcium pyrophosphate dihydate crystal-induced collagenase and stromelysin synthesis by phosphocitrate.. Biochem. Biophys. Acta, 105-111.
    • McCarthy, G. M., Cheung, H. S. (1995).Calcium-containing crystal-induced mitogenesis. Rheum Euro, 262-265.
    • Jasser, M. Z., Mitchell, P. G., Cheung, H. S. (1994).Induction of stromelysin and collagenase synthesis in fibrochondrocytes by tumor necrosis factor-?.. Matrix Biol, 241-249.
    • Cheung, H. S. (1994).Mechanism of destructive Arthropathy and its prevention with phosphocitrate.. Rev. Bras Rheum, 117-119.
    • McCarthy, G. M., Cheung, H. S. (1994).The role of cAMP in prostaglandins-mediated inhibition of basic calcium phosphate crystal-induced mitogenesis and collagenase induction in cultured human fibroblasts.. Biochim Biophys. Acta, 97-104.
    • Rosenthal, A. K., McCarty, B., Cheung, H. S., Ryan, L. M. (1993).Effect of transforming growth factor B1 on pyrophosphate metabolism in porcine articular tissue. Arthritis Rheum, 539-542.
    • Cheung, H. S., Tofe, A. J. (1993).Mechanism of cell growth on calcium phosphate particles: Role of cell mediated dissolution of calcium phosphate matrix.. S.T.P. Pharma Sciences, 51-55.
    • McCarthy, G. M., Mitchell, P. G., Cheung, H. S. (1993).Misoprostol, a PGE1 analogue, inhibits basic calcium phosphate crystal-induced mitogenesis and collagenase accumulation in human fibroblasts. Calcif. Tissue Int., 434-437.
    • Krug, H. E., Mahowald, M. L., Halverson, P. B., Sallis, J. D., Cheung, H. S. (1993).Phosphocitrate prevents disease progression in murine progressive ankylosis.. Arthritis Rheum., 1603-1611.
    • Mitchell, P. G., Cheung, H. S. (1993).Protein kinase regulation of tumor necrosis factor stimulated collagenase and stromelysin message levels in chondrocytes.. Biochem. Biophys. Res. Commun., 1133-1142.
    • McCarthy, G. M., Mitchell, P. G., Struve, J. A., Cheung, H. S. (1992).Basic calcium phosphate crystals cause coordinate induction and secretion of collagenase and stromelysin.. J. Cell Physiol., 140-146.
    • Mitchell, P. G., Struve, J. A., McCarthy, G. M., Cheung, H. S. (1992).Basic calcium phosphate crystals stimulate cell proliferation and collagenase message accumulation in cultured adult articular chondrocytes.. Arthritis Rheum., 343-350.
    • Ryan, L. M., Kurup, I., Cheung, H. S. (1991).Stimulation of cartilage inorganic pyrophosphate elaboration by ascorbate.. Matrix: Collagen & Rel. Res, 276-281.
    • McCarthy, G. M., Mitchell, P. G., Cheung, H. S. (1991).The mitogenic response to stimulation with basic calcium phosphate crystals is accompanied by induction and secretion of collagenase in human fibroblasts.. Arthritis Rheum., 1021-1030.
    • Rosenthal, A. K., Cheung, H. S., Ryan, L. M. (1991).Transforming growth factor B1 stimulates inorganic pyrophosphate elaboration by porcine cartilage.. Arthritis Rheum, 904-911.
    • Mitchell, P. G., Cheung, H. S. (1991).Tumor necrosis factor-a and epidermal growth factor regulation of collagenase and stromelysin in adult porcine articular chondrocytes.. J. Cell Physiol., 132-140.
    • Ryan, L. M., Kurup, I., McCarty, D. J., Cheung, H. S. (1990).Cartilage inorganic pyrophosphate elaboration is independent of sulfated glycosaminoglycan synthesis.. Arthritis Rheum., 235-240.
    • Cheung, H. S., Sallis, J. D., Mitchell, P. G., Struve, J. A. (1990).Inhibition of basic calcium phosphate crystal-induced mitogenesis by phosphocitrate.. Biochem. Biophys.Res. Comm., 20-25.
    • Halverson, P. B., Cheung, H. S., Johnson, R. P., Struve, J. (1990).Simultaneous occurrence of calcium pyrophosphate dihydrate and basic calcium phosphate (hydroxyapatite) crystals in a knee.. Clin. Orthop, & Rel. Res.,, 162-165.
    • Rosenthal, A. K., Cheung, H. S., Ryan, L. M. (1990).Stimulation of pyrophosphate production in articular cartilage by a platelet-derived factor is independent of mitogenesis.. J. Lab. Clin. Med., 352-355.
    • Kenny, D., McCarthy-Kenny, G., Pelc, L. R., Cheung, H. S., Brooks, H. L., Warltier, D. C. (1990).Vasodilator actions of Il-1 in the canine coronary circulation.. Basic Research in Cardiology, 279-284.
    • Rosenthal, A. K., Cheung, H. S., Ryan, L. M. (1989).Augmentation of inorganic pyrophosphate elaboration in cartilage by serum factors.. . Arch. Biochem. Biophys., 386-392.
    • Wortmann, R. L., Veum, J. A., Ryan, L. M., Cheung, H. S. (1989).Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro: A model for the chondro osseous dyplasia of adenosine deaminase deficiency.. . Arthritis Rheum., 1014-1021.
    • Cheung, H. S., Haak , M. H. (1989).Growth of osteoblasts on porous calcium phosphate ceramic: an in vitro model for biocompatibility study. Biomaterials, 10:63-67.
    • Cheung, H. S., Haak, M. H. (1989).Growth of osteoblasts on porous calcium phosphate ceramic: an in vitro model for biocompatibility study.. biomaterials, 63-67.
    • Mitchell, P. G., Pledger, W. J., Cheung, H. S. (1989).Induction of expressions of c-fos and c-myc protooncogenes by basic calcium phosphate crystal: effect of beta interferon. Cancer Research, 49, 134-138.
    • Mitchell, P. G., Pledger, W. J., Cheung, H. S. (1989).Molecular mechanism of basic calcium phosphate crystal-induced mitogenesis: Role of protein kinase C. J. Biol. Chem., 14071-14077.
    • Kwong, C. H., Burns, W. B., Cheung, H. S. (1989).Solubilization of hydroxyapatite crystals by murine bone cells, macrophages and fibroblasts.. Biomaterials, 579-584.
    • Cheung, H. S., McCarty, D. J. (1988).Mechanisms of connective tissue damage by crystals containing calcium.. Rheum Dis Clin N Am, 365-376.
    • Rothenberg, R. J., Cheung, H. S. (1988).Rabbit synoviocyte inositol phospholipid metabolism is stimulated by hydroxyapatite crystals. Am. J. Physiol (Cell Physiol. 23), 254, C554-C559.
    • Rothenberg, R. J., Cheung, H. S. (1988).synoviocyte inositol phospholipid metabolism is stimulated by hydroxyapatite crystals.. Am. J. Physiol, 554-559.
    • Cheung, H. S. (1987).Distribution of types I, II, III, and V in the pepsin solubilized collagens in bovine menisci.. Conn. Tissue Res., 343-356.
    • Borkowf, A., Cheung, H. S., McCarty, D. J. (1987).Endocytosis is required for the mitogenic effect of basic calcium phosphate crystals in fibroblasts.. Calcif. Tissue Int, 173-176.
    • Halverson, P. B., Cheung, H. S., Struve, J., McCarty, D. J. (1987).Suppression of active collagenase from calcified lapine synovium by Arteparon. J. Rheum., 1013-1017.
    • Wortmann, R. L., Veum, J. A., Cheung, H. S. (1986).Adenosine deaminase deficiency and chondro osseous dysplasia.. Adv. Exp. Med. Biol., 81-84.
    • Owens, j. L., Cheung, H. S., McCarty, D. J. (1986).Endocytosis precedes dissolution of basic calcium phosphate crystals by murine macrophages.. Calcif. Tissue Int., 170-174.
    • Cheung, H. S., Van Wyk, J. J., Russell, W. E., McCarty, D. J. (1986).Mitogenic activity of hydroxyapatite: Requirement for somatomedin C.. J. Cell Physiol., 143-148.
    • Lemann, J., Gray, R. W., Maierhofer, W. J., Cheung, H. S. (1986).The importance of renal net acid excretion as a determinant of fasting urinary calcium excretion.. Kidney Int., 743-746.
    • Malawista, S. E., Duff, G. W., Atkins, E., Cheung, H. S., McCarty, D. J. (1985).Crystal induced endogenous pyrogen production: a further look at gouty inflammation.. Arthritis Rheum., 1039-1046.
    • Lemann, J., Gray, R. W., Maierhofer, W. J., Cheung, H. S. (1985).Hydrochlorothiazide inhibits bone resorption in men despite experimentally elevated serum 1,25 dihydroxyvitamin D concentrations.. Kidney Int., 951-958.
    • Cheung, H. S. (1985).In vitro cartilage formation on porous hydroxyapatite ceramic granules.. In Vitro Cell. Develop. Biol, 353-357.
    • Cheung, H. S., Johansen, J. G., Haughton, V. M., Nichols, T. R. (1985).In vitro testing for the risk of arachnoiditis from myelographic contrast media.. Investigative Radiology, 472-475.
    • Cheung, H. S., McCarty, D. J. (1985).Mitogenesis induced by calcium containing crystals: role of intracellular dissolution.. Exp. Cell Res., 63-70.
    • Cheung, H. S., McCarty, D. J. (1985).Prostoglandin (PG) E2 generation by cultured canine synovial fibroblasts exposed to microcrystals containing calcium. Ann. Rheum. Dis, 44, 316-320.
    • Evans, R. W., Cheung, H. S., McCarty, D. J. (1984).Cultured canine synovial cells solubilized 45Ca labeled hydroxyapatite crystals.. Arthritis Rheum., 829-832.
    • Evans, R. W., Cheung, H. S., McCarty, D. J. (1984).Cultured human monocytes and fibroblasts solubilized calcium phosphate crystals.. Calcif. Tissue Int., 645-650.
    • Maierhofer, W. J., Lemann, J., Gray, R. W., Cheung, H. S. (1984).Dietary calcium and serum 1,25(OH)2 vitamin D concentrations as determinants of calcium balance in healthy men. Kidney Int., 752-759.
    • Halverson, P. B., McCarty, D. J., Cheung, H. S., Ryan, L. M. (1984).Milwaukee Shoulder Syndrome: 11 additional cases with involvement of the knee in seven (basic calcium phosphate crystal deposition disease).. Sem. Arthritis Rheum, 36-44.
    • Cheung, H. S., Story, M. T., McCarty, D. J. (1984).Mitogenic effects of hydroxyapatite and calcium pyrophosphate dihydate crystals on cultured mammalian cells.. Arthritis Rheum., 668-674.
    • Maierhofer, W. J., Gray, R. W., Cheung, H. S., Lemann, J. (1983).Bone resorption stimulated by elevated serum 1,25 (OH)2 vitamin D concentrations in healthy men.. Kidney Int., 555-560.
    • Cheung, H. S., Bohon, S., Kozin, F. (1983).Kinetics of collagenase and neutral protease release by neutrophils exposed to microcrystalline sodium urate.. Conn. Tissue Res., 79-85.
    • Landow, R. K., Cheung, H. S., Bauer, M. (1983).Papillon-Lefevre syndrome. Int. J. Trop. Dermatology, 177-179.
    • Cheung, H. S., Halverson, P. B., McCarty, D. J. (1983).Phagocytosis of hydroxyapatite or calcium pyrophosphate dihydate crystals by rabbit articular chondrocytes stimulates release of collagenase, neutral protease and prostaglandins E2 and F2. Proc. Soc. Exp. Biol. Med., 181-189.
    • Adams, N. D., Gray, R. W., Cheung, H. S., Lemann, J. (1982).Effects of calcitriol administration on calcium metabolism in healthy men.. Kidney Int., 90-97.
    • Halverson, P. B., Cheung, H. S., McCarty, D. J. (1982).Enzymatic release of microspheriods containing hydroxyapatite crystals from synovium and of calcium pyrophosphate dihydrate crystals from cartilage.. Ann. Rheum. Dis., 527-531.
    • Cheung, H. S., Landow, R. K., Bauer, M. (1982).Increased collagen synthesis by gingival fibroblasts derived from a Papillon-Lefevre patient.. J. Dental Research, 378-381.
    • McCarty, D. J., Cheung, H. S. (1982).Origin and significance of rice bodies in synovial fluid.. Lancet, 715-716.
    • Ryan, L. M., Cheung, H. S., Schwab, J. P., Johnson, R. P. (1982).Predominance of type II collagen in synovial chondromatosis.. Clin. Orthop. & Rel. Res, 173-177.
    • McCarty, D. J., Cheung, H. S., Halverson, P. B., Garancis, J. C. (1981)."Milwaukee Shoulder" syndrome: Microspherules containing hydroxyapatite, active collagenase and neutral protease in patients with rotator cuff defects and glenohumoral osteoarthritis. Seminars in Arthritis Rheum., 119-121.
    • Halverson, P. B., Cheung, H. S., McCarty, D. J., Garancis, J. C., Mandel, N. (1981)."Milwaukee Shoulder"-association of microspheroids containing hydroxyapatite crystals, active collagenase, and neutral protease with rotator cuff defects. II. Synovial fluid studies.. Arthritis Rheum., 474-483.
    • Garancis, J. C., Cheung, H. S., Halverson, P. B., McCarty, D. J. (1981)."Milwaukee Shoulder"-association of microspheroids containing hydroxyapatite crystals, active collagenase, and neutral protease with rotator cuff defects. III. Morphologic and biochemical studies of an excised synovium showing chondromatosis. Arthritis Rheum., 484-491.
    • Cheung, H. S., Ryan, L. M. (1981).A method of determining DNA and chondrocyte content of articular cartilage.. Anal. Biochem, 93-97.
    • Cheung, H. S., Halverson, P. B., McCarty, D. J. (1981).Release of collagenase, neutral protease, and prostaglandins from cultured mammalian synovial cells by hydroxyapatite and calcium pyrophosphate dihydrate crystals.. Arthritis Rheum., 1338-1344.
    • Ryan, L. M., Cheung, H. S., McCarty, D. J. (1981).Release of pyrophosphate by normal mammalian articular hyaline and fibrocartilage in organ culture.. Arthritis Rheum., 1522-1527.
    • Cheung, H. S. (1980).An improved method of establishing human fibroblast cultures from explants.. J. Tissue Culture Methods, 39-40.
    • Cheung, H. S., Ryan, L. M., Kozin, F., McCarty, D. J. (1980).Identification of collagen subtypes in synovial fluid sediments from arthritic patients.. Amer. J. Med, 73-79.
    • Cheung, H. S., Singer, F. R., Mills, B., Nimni, M. E. (1980).In vitro synthesis of normal bone (type I) collagen by bones of Paget?s disease patients.. Proc. Soc. Exp. Biol. Med., 547-552.
    • Cheung, H. S., Lynch, K. L., Johnson, R. P., Brewer, B. J. (1980).In vitro synthesis of tissue-specific Type II collagen by healing cartilage: I. Short-term repair of cartilage by mature rabbits.. Arthritis Rheum., 211-219.
    • Cheung, H. S., Ryan, L. M., Kozin, F., McCarty, D. J. (1980).Synovial origins of rice bodies in joint fluid. Arthritis Rheum., 72-76.
    • Cheung, H. S., Cottrell, W. H., Stephenson, K., Nimni, M. E. (1978).In vitro collagen biosynthesis in healing and normal rabbit articular cartilage. J. Bone Joint Surg., 1076-1081.
    • Cheung, H. S., Nicoloff, J. T., Kamiel, M. B., Spolter, L., Nimni, M. E. (1978).Stimulation of fibroblast biosynthetic activity by serum of patients with Pretibial Myxedema. J. Invest. Derm., 17-Dec.
    • OBrien, T. J., Liebke, H. H., Cheung, H. S. (1976).Isoelectric focusing in a Sephadex column. Anal. Biochem, 38-44.
    • Cheung, H. S., Harvey, W., Benya, P. D., Nimni, M. E. (1976).New collagen markers of derepression synthesized by rabbit articular chondrocytes in culture.. Biochem. Biophys. Res. Comm., 1371-1378.
  • Book Chapters

    • Ng, ., Pelaez, D., Fortino, V., Cheung, H. S., (2013). A Potentially Revolution in Regenerative Medicine and Tissue Engineering. In Pluripotent Stem Cells (pp. 26-38 (Ch. 2)). .
    • Laberge, T., Cheung, H. S., (2011). Multipotent dental stem cells: an alternative adult derived stem cell source for regenerative medicine. Embryonic Stem Cells - Differentiation and Pluripotent Alternatives, -- Chapter: 23 (pp. 451-472 (Ch. 23)). Bentham Science Publishers.
    • Pelaez, D., Hare, J. M., Cheung, H. S., (2011). The role of mechanical force on cardiomyocytes differentiation of stem cells. Stem Cell Microenvironments and Tissue Engineering (pp. ). World Scientific Publishing Co. Inc..
    • Dang, S., Golden, A., Cheung, H. S., Roos, B. A., (2010). . Telemedicine Applications in Geriatrics.. Brocklehurst's Textbook on Geriatric Medicine and Gerontology -- Chapter: 128 (pp. 1064-1070). Elsevier.
    • Pelaez, D., Fritz, J. R., Cheung, H. S., Cheung, H. S (Ed.). (2010). The role of mechanical forces on stem cell growth and differentiation -- Chapter: 4. Stem Cells and Regenerative Medicine, E-Book Series (pp. 35-48). Bentham Science Publishers.
    • Cheung, H. S., Cheung, H. S (Ed.). (2010). Stem Cells and Regenerative Medicine, E-Book Series. E-Book Series (pp. 1-125). Bentham Science Publishers.
    • Cheung, H. S (Ed.). (2009). Stem Cells, Cartilage Repair, and Osteoarthritis. (pp. ). Special Issue Current Rheumatology Review.
    • Dang, S., Golden, A., Cheung, H. S., Roos, B. A., (2009). Telemedicine Applications in Geriatrics -- Chapter: 128. Brocklehurst's Textbook on Geriatric Medicine and Gerontology, 7th Ed. (pp. 1064-1070). Elsevier.
    • Cheung, H. S., (2006). Biological Effects of Calcium-containing Crystals -- Chapter: 17. Crystal-induced Arthropathies (pp. 277-286). Taylor & Francis Group.
    • Cheung, H. S., (2006). Therapeutic Strategies for Calcium-containing Crystal Arthropathies -- Chapter: 26. Crystal-induced Arthropathies (pp. 411-419). Taylor & Francis Group.
    • Sallis, J. D., Wierzbicki, A., Cheung, H. S., (2001). Calcium pyrophosphate crystal forms and the influence of phosphocitrate -- Chapter: 5. Advance in Crystal Growth Inhibition Technologies (pp. 57-70). Plenum Publishers.
    • Ryan, L. M., Cheung, H. S., (1999). The role of crystals in osteoarthritis. Osteoarthritis Rheumatic Disease of America (pp. 257-267). W.B. Saunders Co..
    • Cheung, H. S., Ryan, L. M., (1993). Role of crystal deposition in matrix degradation. Joint Cartilage Degradation: Basic and Clinical Aspects (pp. 209-223). Marcel Dekker, Inc..
    • Cheung, H. S., McCarty, D. J., (1985). Biological effects of calcium-containing crystals on synoviocytes. Calcium in Biological Systems (pp. 719-724). Pleum Press.
    • Halverson, P. B., Cheung, H. S., Garancis, J. C., McCarty, D. J., (1982). Rotator cuff defects and glenohumeral osteoarthritis associated with synovial fluid hydroxyapatite collagenase and neutral protease. Clinical Trends in Orthopaedic (pp. 86-94). Thieme-Stratton, Inc..