Fabrice Manns

Photo of Fabrice Manns

Fabrice Manns

Professor and Chair | College of Engineering | Biomedical Engineering Department
Work Phone: (305) 284-2335


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Research Interests

Optics of the eye and vision correction, Applications of lasers and optics in medicine, Optical imaging, Ophthalmic technologies

HIGHER EDUCATION

    • University of Miami, Ph.D. in Department of Biomedical Engineering (1996)
    • University of Bordeaux I, Bordeaux, France, M.S. in Microelectronics (Diplome d'Etudes Approfondies) (1991)
    • Ecole Nationale Superieure d'Electronique et de Radioelectricite de Bordeaux, Bordeaux, France, B.S. in Electrical Engineering (1991)

EXPERIENCE

    • University of Miami, Chair, Department of Biomedical Engineering. (2017 - Present)
    • University of Miami, Professor of Biomedical Engineering and Ophthalmology. College of Engineering (School of Medicine Secondary Appointment) (2013 - Present)
    • Bascom Palmer Eye Institute, University of Miami, Co-Director, Ophthalmic Biophysics Center. School of Medicine (2001 - Present)
    • Department of Biomedical Engineering, University of Miami, Director, Biomedical Optics Laboratory. (1997 - Present)
    • Department of Biomedical Engineering, University of Miami, Graduate Program Director. College of Engineering (2009 - 2016)
    • Department of Biomedical Engineering, University of Miami, Associate Chairman. College of Engineering (2008 - 2016)
    • Department of Biomedical Engineering, University of Miami, Acting Chair. College of Engineering (2013 - 2014)
    • University of Miami, Associate Professor of Biomedical Engineering and Ophthalmology (with tenure). College of Engineering (School of Medicine Secondary Appointment) (2006 - 2013)
    • University of Miami, Assistant Professor of Biomedical Engineering and Ophthalmology. College of Engineering (School of Medicine Secondary Appointment) (2000 - 2006)
    • University of Miami, Research Assistant Professor of Biomedical Engineering and Ophthalmology. College of Engineering (School of Medicine Secondary Appointment) (1997 - 2000)
    • University of Miami, Adjunct Instructor of Biomedical Engineering. College of Engineering (1996 - 1997)
    • University of Miami School of Medicine, Post-doctoral Associate, Department of Ophthalmology. (1996 - 1997)
    • University of Miami, Graduate Research Assistant, Department of Biomedical Engineering. College of Engineering (1992 - 1996)
    • University of Bordeaux I, Research Engineer, IXL Microelectronics Laboratory. IXL Microelectronics Laboratory (1991 - 1992)
    • University of Bordeaux I, Research Assistant, IXL Microelectronics Laboratory. IXL Microelectronics Laboratory (1991)
    • European Molecular Biology Laboratory, Heidelberg, Germany, Trainee, Confocal Microscopy Group. Confocal Microscopy Group (1990)

PUBLICATIONS

  • Juried or Refereed Journal Articles or Exhibitions

    • Chang, Y., Liu, K., Cabot, F., Ho, A., Manns, F. (2018).Variability of manual ciliary muscle segmentation in optical coherence tomography images. Biomedical Optics Express, 9, 791-800.
    • Chang, Y. C., Liu, K., de Freitas, C., Pham, A., Cabot, F., Adre, E., Ho, A., Parel, J. M., Manns, F. (2017).Assessment of eye length changes in accommodation using dynamic extended-depth OCT.. Biomedical optics express, 8, 2709-2719. http://doi.org/10.1364/BOE.8.002709
    • de Freitas, C., Hernandez, V. M., Cabot, F., Yesilirmak, N., Alawa, K., Chang, Y. C., Parel, J. M., Manns, F. (2016).Quantification of the ciliary muscle and crystalline lens interaction during accommodation with synchronous OCT imaging.. Biomedical optics express, 7, 1351-64. http://doi.org/10.1364/BOE.7.001351
    • Wu, C., Han, Z., Wang, S., Li, J., Singh, M., Liu, C., Aglyamov, S., Emelianov, S., Manns, F., Larin, K. V. (2015).Assessing age-related changes in the biomechanical properties of rabbit lens using a co-aligned ultrasound and optical coherence elastography system. Investigative Ophthalmology and Visual Science, 56, 1292-1300.
    • De Freitas, C., Cabot, F., Culbertson, W., Yoo, S., Parel, J., Manns, F. (2015).Calculation of ophthalmic viscoelastic device-induced focus shift during femtosecond laser-assisted cataract surgery. Investigative Ophthalmology and Visual Science, 56, 1222-1227.
    • Maceo-Heilman, B., Manns, F., De Castro, A., Durkee, H., Arrieta, E., Marcos, S., Parel, J. (2015).Changes in monkey crystalline lens spherical aberration during simulated accommodation in a lens stretcher. Investigative Ophthalmology and Visual Science, 56, In Press (published online).
    • Pour, H. M., Kanapathipillai, S., Zarrabi, K., Manns, F., Ho, A. (2015).Stretch-dependent changes in surface profiles of the human crystalline lens during accommodation: A finite-element study. Clinical and Experimental Optometry, 98, 126-137.
    • Nankivil, D., Maceo, B., Durkee, H., Manns, F., Ehrmann, K., Kelly, S., Arrieta-Quintero, E., Parel, J. (2015).The zonules selectively alter the shape of the lens during accommodation based on the location of their anchorage points. Investigative Ophthalmology and Visual Science, 56, In Press (published online).
    • Hernandez, V. M., Cabot, F., de Freitas, C., Ho, A., Parel, J. M., Manns, F. (2015).Calculation of crystalline lens power using a modification of the Bennett method.. Biomedical optics express, 6, 4501-15. http://doi.org/10.1364/BOE.6.004501
    • Marussich, L., Manns, F., Nankivil, D., Maceo Heilman, B., Yao, Y., Arrieta-Quintero, E., Ho, A., Augusteyn, R., Parel, J. (2015).Measurement of crystalline lens volume during accommodation in a lens stretcher. Investigative Ophthalmology and Visual Science, 56, 4239-4248.
    • Wang, S., Aglyamov, S., Karpiouk, A., Li, J., Emelianov, S., Manns, F., Lirin, K. (2013).Assessing the mechanical properties of tissue-mimicking phantoms at different depths as an approach to measure biomechanical gradient of crystalline lens. Biomedical Optics Express, 4(12), 2769-2780.
    • deFreitas, C., Ruggeri, M., Manns, F., Ho, A., Parel, J. (2013).In vivo measurement of the average refractive index of the human crystalline lens using optical coherence tomography. Optics Letters, 38, 85-87.
    • De Castro, A., Birkenfeld, J., Maceo, B., Arrieta, E., Manns, F., Parel, J., Marcos, S. (2013).Influence of shape and gradient refractive index in the accommodative changes of spherical aberration in non-human primate crystalline lenses. Investigative Ophthalmology and Visual Science, 54(9), 6197-6207.
    • Siedlecki, D., de Castro, A., Gambra, E., Ortiz, S., Borja, D., Uhlhorn, S., Manns, F., Marcos, S., Parel, J. (2012).Distortion correction of OCT images of the crystalline lens: Gradient-Index approach. Optometry and Vision Science, 89, E709-E718.
    • Hao, X., Jeffery, J., Le, T., McFarland, G., Johnson, G., Mulder, R., Garrett, Q., Manns, F., Nankivil, D., Arrieta, E., Ho, A., Parel, J., Hughes, T. (2012).High refractive index polysiloxane as injectable, in situ curable accommodating intraocular lens biomaterials. Biomaterials, 33, 5659-5671.
    • Ruggeri, M., Uhlhorn, S., De Freitas, C., Ho, A., Manns, F., Parel, J. (2012).Imaging and full-length biometry of the eye during accommodation using Spectral-Domain OCT with an optical switch. Biomedical Optics Express, 3, 1506-1520.
    • Augusteyn, R., Mohamed, A., Nankivil, D., Veerendranath, P., Arrieta, E., Taneja, M., Manns, F., Ho, A., Parel, J. (2011).Age-dependence of the optomechanical responses of ex vivo human lenses from India and the USA, and the force required to produce these in a lens stretcher: the similarity to in vivo disaccommodation. Vision Research, 51, 1667-1678.
    • de Castro, A., Siedlecki, D., Borja, D., Uhlhorn, S., Parel, J., Manns, F., Marcos, S. (2011).Age-dependent variation of the Gradient Index profile in human crystalline lenses. Journal of Modern Optics, 58, 1781-1787.
    • Maceo, B., Manns, F., Borja, D., Nankivil, D., Uhlhorn, S., Arrieta, E., Ho, A., Augusteyn, R., Parel, J. (2011).Contribution of the crystalline lens gradient refractive index to the accommodation amplitude in non?human primates: in vitro studies. Journal of Vision, 11, 13:23.
    • Ale, J., Manns, F., Ho, A. (2011).Magnifications of single and dual element accommodative intraocular lenses: Paraxial optics analysis. Ophthalmic and Physiological Optics, 31, 7-16.
    • Ale, J., Manns, F., Ho, A. (2011).Paraxial analysis of the depth-of-field of a pseudophakic eye implanted with Accommodating IOLs. Optometry and Vision Science, 88, 789-794.
    • Chou, T., Kocaoglu, O., Borja, D., Ruggeri, M., Uhlhorn, S., Manns, F., Porciatti, V. (2011).Postnatal elongation of eye size in DBA/2J mice compared with C57BL/6J mice: In vivo analysis with whole-eye OCT. Investigative Ophthalmology and Visual Science, 52, 3604-3612.
    • Ziebarth, N., Arrieta, E., Moy, V., Manns, F., Parel, J. (2011).Primate lens capsule elasticity assessed using Atomic Force Microscopy. Experimental Eye Research, 92, 490-494.
    • Urs, R., Ho, A., Manns, F., Parel, J. (2010).Age-dependent Fourier model of the shape of the isolated ex vivo human crystalline lens. Vision Research, 50, In press.
    • Borja, D., Siedlecki, D., De Castro, A., Uhlhorn, S., Ortiz, S., Arrieta, E., Parel, J., Marcos, S., Manns, F. (2010).Distortions of the posterior surface in optical coherence tomography images of the isolated crystalline lens: Effect of the lens index gradient. Biomedical Optics Express, 1, 1331-1340.
    • Ale, J., Manns, F., Ho, A. (2010).Evaluation of the performance of accommodating IOL using paraxial optics analysis. Ophthalmic and Physiological Optics, 30, 132-142.
    • Borja, D., Manns, F., Ho, A., Ziebarth, N., Acosta, A. C., Arrieta, E., Augusteyn, R. C., Parel, J. M. (2010).Optical power and biometric properties of the non-human primate isolated crystalline lens. Investigative Ophthalmology and Visual Science, 51, 2118-2125.
    • Fedke, C., Manns, F., Ho, A. (2010).The entrance pupil of the human eye: a three-dimensional model as a function of viewing angle. Optics Express, 18, 22364-22376.
    • Nankivil, D., Manns, F., Arrieta-Quintero, E., Ziebarth, N., Borja, D., Amelinckx, A., Bernal, A., Ho, A., Parel, J. M. (2009).Effect of anterior zonule transection on the change in lens diameter and power in cynomolgus monkeys during simulated accommodation. Investigative Ophthalmology and Visual Science, 50, 4017-4021.
    • Urs, R., Manns, F., Ho, A., Borja, D., Amelinckx, A., Smith, J., Jain, R., Augusteyn, R., Parel, J. M. (2009).Shape of the isolated ex-vivo human crystalline lens. Vision Research, 49, 74-83.
    • Yoo, S., Kymionis, G., Deobhakta, A., Ide, T., Manns, F., Culbertson, W., O'Brien, T., Alfonso, E. (2008).One-year results and anterior segment Optical Coherence Tomography findings of Descemet Stripping Automated Endothelial Keratoplasty combined with phacoemulsification. Archives of Ophthalmology, 126, 1052-1055.
    • Borja, D., Manns, F., Ho, A., Ziebarth, N., Rosen, A., Jain, R., Amelinckx, A., Arrieta, E., Augusteyn, R., Parel, J. (2008).Optical power of the isolated human crystalline lens. Investigative Ophthalmology and Visual Science. NONE, 49, 2541-2548.
    • Uhlhorn, S., Borja, D., Manns, F., Parel, J. (2008).Refractive index measurement of the isolated crystalline lens using optical coherence tomography. Vision Research, 48, 2732-2738.
    • Ziebarth, N., Wojcikiewicz, E., Manns, F., Moy, V., Parel, J. (2007).Atomic Force Microscopy measurements of lens elasticity in monkey eyes. Molecular Vision, 13, 504-510.
    • Manns, F., Parel, J., Denham, D., Billotte, C., Ziebarth, N., Borja, D., Fernandez, V., Arrieta, E., Aly, M., Ho, A., Holden, B. (2007).Optomechanical response of human and monkey lenses in a lens stretcher. Investigative Ophthalmology and Visual Science, 48, 3260-3268.
    • Kocaoglu, O., Uhlhorn, S., Hernandez, E., Juarez, R., Will, R., Parel, J., Manns, F. (2007).Simultaneous fundus imaging and optical coherence tomography of the mouse retina. . Investigative Ophthalmology and Visual Science, 48, 1283-1289.
    • Parel, J., Ziebarth, N., Denham, D., Fernandez, V., Manns, F., Lamar, P., Rosen, A., Ho, A., Erickson, P. (2006).Assessment of the strength of mini-capsulorhexes. Journal of Cataract and Refractive Surgery, 32, 1366-1373.
    • Bernal, A., Parel, J., Manns, F. (2006).Evidence for posterior zonular fiber attachment on the anterior hyaloid membrane. Investigative Ophthalmology and Visual Science, 47, 4708-4713.
    • Rosen, A., Denham, D., Fernandez, V., Borja, D., Ho, A., Manns, F., Parel, J., Augusteyn, R. (2006).In vitro lens dimensions and curvatures of human lenses. Vision Research, 46, 1002-1009.
    • Ho, A., Manns, F., Pham, T., Parel, J. (2006).Predicting the performance of accommodating intra-ocular lenses using ray-tracing.. Journal of Cataract and Refractive Surgery, 32, 129-136.
    • Ziebarth, N., Manns, F., Parel, J. (2005).Fiber-optic focus detection system for non-contact high resolution thickness measurement of transparent tissues. Journal of Physics D: Applied Physics, 38, 2708-2715.
    • Ziebarth, N., Manns, F., Uhlhorn, S., Venkatraman, A., Parel, J. (2005).Non-contact optical measurement of lens capsule thickness in human, monkey, and rabbit postmortem eyes. Investigative Ophthalmology and Visual Science, 46, 1690-1697.
    • Yavuz, E., Morawski, K., Telischi, F., Ozdamar, O., Delgado, R., Manns, F., Parel, J. (2005).Simultaneous measurement of electrocochleography and cochlear blood flow during cochlear hypoxia in rabbits. Journal of Neuroscience Methods., 147, 55-64.
    • Borja, D., Manns, F., Lamar, P., Rosen, A., Fernandez, V., Parel, J. (2004).Preparation and hydration control of corneal tissue strips for experimental use. Cornea, 23, 61-66.
    • Manns, F., Fernandez, V., Zipper, S., Sandadi, S., Hamaoui, M., Ho, A., Parel, J. (2004).Radius of curvature and asphericity of the anterior and posterior surface of human cadaver crystalline lenses. Experimental Eye Research, 78, 39-51.
    • Salas, N., Manns, F., Milne, P., Denham, D., Minhaj, A., Parel, J., Robinson, D. (2004).Thermal analysis of laser interstitial thermotherapy in ex-vivo fibro-fatty tissue using exponential functions. Physics in Medicine and Biology, 49, 1609-1624.
    • Manns, F., Borja, D., Parel, J., Smiddy, W., Culbertson, W. (2003).Semi-analytical thermal model for sub-ablative laser heating of homogeneous non-perfused biological tissue: Application to laser thermokeratoplasty. Journal of Biomedical Optics, 8, 288-297.
    • Manns, F., Ho, A., Parel, J., Culbertson, W. (2002).Ablation profiles for wavefront-guided correction of myopia and primary spherical aberration. Journal of Cataract and Refractive Surgery, 28, 766-774.
    • Mizota, A., Takasoh, M., Kobayashi, K., Parel, J., Manns, F., Rol, P. (2002).Internal sclerostomy with the Er:YAG laser using a gradient-index (GRIN) endoscope. Ophthalmic Surgery and Lasers, 33, 214-220.
    • Minhaj, A., Manns, F., Milne, P., Denham, D., Salas, N., Nose, I., Damgaard-Iversen, K., Parel, J., Robinson, D. (2002).Laser interstitial thermotherapy (LITT) monitoring using high-resolution digital mammography: Theory and experimental studies. Physics in Medicine and Biology, 47, 2987-2999.
    • Manns, F., Milne, P., Parel, J. (2002).UV corneal photoablation. Journal of Refractive Surgery, 18, S610-S614.
    • Ho, A., Erickson, P., Manns, F., Pham, T., Parel, J. (2001).Theoretical analysis of accommodation amplitude and ametropia correction by varying refractive index in phaco-ersatz. Optometry and Vision Science, 78, 405-410.
    • Milne, P., Parel, J., Manns, F., Denham, D., Gonzalez-Cirre, X., Robinson, D. (2000).Development of stereotactically-guided laser interstitial thermotherapy (LITT) of breast cancer: in-situ measurement and analysis of the temperature field in ex vivo and in vivo adipose tissue. Lasers in Surgery and Medicine, 26, 67-75.
    • Rol, P., Huber, C., Manns, F., Parel, J. (1999).ArF Photoablation of Keratoprostheses. Annales Instituto Barraquer (Barcelona), 28, 127-130.
    • Manns, F., Milne, P., Gonzalez-Cirre, X., Denham, D., Parel, J., Robinson, D. (1998).In-situ temperature measurements with thermocouple probes during laser interstitial thermotherapy (LITT): Quantification of a measurement artifact. Lasers in Surgery and Medicine, 23, 94-103.
    • Robinson, D., Parel, J., Denham, D., Gonzalez-Cirre, X., Manns, F., Milne, P., Schachner, R., Herron, A., Comander, J., Hauptman, G. (1998).Interstitial laser hyperthermia model development for minimally invasive therapy of breast carcinoma. Journal of the American College of Surgeons, 186, 284-292.
    • Sasoh, M., Parel, J., Manns, F., Nose, I., Comander, J., Smiddy, W. (1998).Quantification of Ho:YAG and Tm:YAG laser-induced scleral shrinkage for buckling procedures. Ophthalmic Surgery and Lasers, 29, 410-421.
    • Shen, J., Joos, K., Manns, F., Denham, D., Ren, Q., Fankhauser, F., Soderberg, P., Parel, J. (1997).Ablation rate of cornea and PMMA with a frequency-quintupled Nd:YAG laser. Lasers in Surgery and Medicine, 21, 179-185.
    • Yamanaka, A., Miyazaki, S., Manns, F., Hayashi, H., Parel, J. (1997).In vitro study of laser photo-ablative optic nerve sheath decompression with the Erbium:YAG and Thulium:YAG lasers. Acta Medica Hyogoensia, 22, 251-257.
    • Manns, F., Rol, P., Shen, J., Soderberg, P., Matsui, T., Parel, J. (1996).Optical profilometry of poly(methylmethacrylate) (PMMA) surfaces after reshaping with a scanning photorefractive keratectomy (SPRK) system. Applied Optics, 35, 3338-3346.
    • Robinson, D., Parel, J., Denham, D., Manns, F., Gonzalez, X., Schachner, R., Herron, A., Burdette, E. (1996).Stereotactic uses beyond core biopsy: model development for minimally invasive treatment of breast cancer through interstitial laser hyperthermia. American Surgeon, 62, 117-118.
    • Manns, F., Shen, J., Söderberg, P., Matsui, T., Parel, J. (1995).Development of an algorithm for corneal reshaping with a scanning beam. Applied Optics, 34, 4600-4608.
  • Refereed Books

    • Manns, F. (Ed.) The correction of ametropia by photoablation of the cornea with a scanning beam. University of Miami Dissertation.

    Book Chapters

    • Sueiras, V. M., Manns, F., (2017). Biomechanics of the lens and its role in accommodation. Biomechanics of the Eye (pp. ). Kugler Publications.
    • Dawson, D., Manns, F., Lee, Y., (2008). Principles and Ablation Profiles: Myopia, Hyperopia, and Astigmatism; Chapter 88 . Corneal Surgery, Theory, and Technique and Tissue, Fourth Edition (pp. ). Mosby-Elsevier, Philadelphia.
    • Parel, J., Manns, F., Holden, B., Ho, A., (2006). Refractive surgical procedures to restore accommodation; Chapter 40 . Refractive Surgery, 2nd Edition (pp. 501-509). Mosby-Elsevier, Philadelphia.
    • Manns, F., Ho, A., , . (2004). Chapter 42. Customized visual correction of presbyopia in Wavefront-guided corrections: The quest for super vision, 2nd Edition (pp. 353-360). SLACK Inc, Thorofare, NJ.
    • Ho, A., Erickson, P., Manns, F., Fernandez, V., Parel, J., (2003). The limits of simultaneous ametropia correction in phaco-ersatz . Hyperopia and Presbyopia (pp. 259-277). Marcel Dekker, New York.

 

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