Dr. Farshid Guilak – CoE Strategic Research Initiatives Seminars

“Engineering New Biologic Therapies for Arthritis”

Farshid Guilak, PhD
Professor and Director
Center of Regenerative Medicine and Shriners Hospitals for Children – St. Louis
Departments of Orthopaedic Surgery, Developmental Biology, and Biomedical Engineering
Washington University, St. Louis

Monday, Nov. 5, 2018 | 6:00 p.m.

McArthur Engineering Addition, Jose Milton Leadership Hall, Room 202
1251 Memorial Drive
Coral Gables, FL 33146

Abstract
Osteoarthritis is a painful and debilitating disease of the joints that is characterized by progressive degeneration of the articular cartilage. Using a hierarchical approach, we have identified specific mechanobiologic signaling pathways that regulate cartilage physiology, pathology and regeneration. These pathways provide novel pharmacologic targets for the modification of cartilage disease and repair. Additionally, our studies have focused on stem cell-based approaches for repairing cartilage damage. Using a combination of principles of synthetic biology and genome engineering, we have rewired cellular gene circuits to allow creation of a unique, custom-designed cell type that can sense and respond to its biochemical environment in a pre-programmed way to developed engineered tissues with the ability for tunable, inducible or auto-regulated biological responses.

Farshid Guilak, PhD, is a professor of orthopaedic surgery at Washington University, director of research for the St. Louis Shriners Hospitals for Children, and co-director of the Washington University Center of Regenerative Medicine, with appointments in the departments of developmental biology and biomedical engineering. His laboratory is pursuing a multidisciplinary approach to investigate the etiology and pathogenesis of various musculoskeletal diseases – particularly arthritis – as a basis for developing new bioengineering-based therapies. He has published more than 300 articles in peer-reviewed journals and has co-edited four books. Guilak is the editor-in-chief of the Journal of Biomechanics, associate editor for Osteoarthritis & Cartilage, and serves on several other journal editorial boards. He is also the founder and president of Cytex Therapeutics, a startup company focusing on developing new regenerative medicine therapies for musculoskeletal conditions.

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View the presentation live: coe.miami.edu/speaker/guilak


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