Publications

Selected peer-reviewed journal papers:

  • Huang C-Y, Mow VC, Ateshian GA: The Role of Flow-Independent Viscoelasticity in the Biphasic Tensile and Compressive Responses of Articular Cartilage, Journal of Biomechanical Engineering 123:410-7, 2001. PMID:11601725
  • Huang C-Y, Soltz MA, Kopacz M, Mow VC, Ateshian GA: Experimental Verification of the Role of Intrinsic Matrix Viscoelasticity and Tension-Compression Nonlinearity in the Biphasic Response of Cartilage in Unconfined Compression. Journal of Biomechanical Engineering 125:84-93, 2003. PMID:12661200
  • Gu WY, Yao H, Huang C-Y, Cheung HS: New Insight into Deformation-Dependent Hydraulic Permeability and Dynamic Compressive Behavior of Agarose Gels. Journal of Biomechanics 36:593-8, 2003. PMID: 12600349
  • Huang C-Y, Reuben PM, D’Ippolito G, Schiller PC, Cheung HS: Chondrogenesis of Human Bone Marrow Derived Mesenchymal Stem Cell in Agarose Culture. Anatomical Record 278A:428-36, 2004. PMID: 15103737
  • Huang C-Y, Hagar CL, Frost LE, Sun Y, Cheung HS: Effects of Cyclic Compressive Loading on Chondrogenesis of Rabbit Bone-Marrow Derived Mesenchymal Stem Cells. Stem Cells 22:313-323, 2004. PMID: 15153608
  • Huang C-Y, Stankiewicz A, Ateshian GA, Mow VC: Anisotropy, Inhomogeneity, Tension-Compression Nonlinearity of Human Glenohumeral Cartilage in Finite Deformation. Journal of Biomechanics 38:799-809, 2005. PMID: 16023009
  • Huang C-Y, Pawluk RJ, Wang VM, Bucchieri JS, Levine WN, Bigliani LU, Mow VC, Flatow EL: Inhomogeneous Mechanical Behavior of the Human Supraspinatus Tendon Under Uniaxial Loading. Journal of Orthopaedic Research 23: 924-30, 2005. PMID: 16023009
  • Huang C-Y, Reuben PM, Cheung HS: Temporal Expression Patterns and Corresponding Protein Inductions of Early Responsive Genes in Rabbit Bone-Marrow Derived Mesenchymal Stem Cells Under Cyclic Compressive Loading. Stem Cells 23:1113-1121, 2005. PMID:15955834
  • Huang C-Y, Deitzer MA, Cheung HS: Effects of Fibrinolytic Inhibitors on Chondrogenesis of Bone Marrow Mesenchymal Stem Cells in Fibrin Gels. Journal of Biomechanics and Modeling in Mechanobiology 6:5-11, 2007. PMID: 16691415
  • Huang C-Y, Gu WY. Effects of Tension-compression Nonlinearity on Solute Transport in Charged Hydrated Fibrous Tissues under Dynamic Unconfined Compression. Journal of Biomechanical Engineering 129:423-9, 2007. PMID:17536910
  • Huang C-Y, Yuan T-Y, Jackson AR, Hazbun L, Fraker C, Gu WY. Effects of Low Glucose Concentrations on Oxygen Consumption Rates of Intervertebral Disc Cells. Spine 32:2063-9, 2007. PMID:17762806
  • Jackson AR, Yuan T-Y, Huang C-Y, Travascio F, Gu WY. Effect of Compression and Anisotropy on the Diffusion of Glucose in Annulus Fibrosus. Spine 33:1-7, 2008. PMID:1816574
  • Huang C-Y, Gu WY. Effects of Mechanical Compression on Metabolism and Distribution of Oxygen and Lactate in Intervertebral Disc. Journal of Biomechanics 41:1184-96, 2008. PMID:18374341
  • Pelaez D, Huang C-Y, Cheung HS. Dynamic Compression Maintains Viability and Induces Chondrogenesis of Human Mesenchymal Stem Cells in Fibrin Gel Scaffolds. Stem Cells and Development 18: 93-102, 2009. PMID:18399763
  • Flagler D, Huang C-Y, Yuan T-Y, Lu Z, Cheung HS, Gu WY. Intracellular Flow Cytometric Measurement of Extracellular Matrix Components in Porcine Intervertebral Disc Cells. Cellular and Molecular Bioengineering 2:264-273, 2009. PMID:20161070
  • Yuan T-Y, Jackson AR, Huang C-Y, Gu WY. Strain-dependent Diffusion Coefficient of Oxygen in Bovine Annulus Fibrosus. Journal of Biomechanical Engineering, 131:074503, 2009. PMID:19640139
  • Jackson AR, Yuan T-Y, Huang C-Y, Gu WY: A Conductivity Approach to Measuring Fixed Charge Density in Interverteral Disc Tissue. Annals of Biomedical Engineering, 12: 2566-2573, 2009. PMID: 19757059
  • Huang C-Y, Pelaez D, Dominguez Bendala J, Garcia-Godoy F, Cheung HS. Plasticity of Stem Cells Derived from Adult Periodontal Ligament. Regenerative Medicine, 4:809-21, 2009.
  • Chadipiralla K, Yochim JM, Bahuleyan B, Huang C-Y, Garcia-Godoy F, Murray PE, Stelnicki EJ. Osteogenic Differentiation of Stem Cells Derived From Human Periodontal Ligaments and Pulp of Human Exfoliated Deciduous Teeth. Cell and Tissue Research, 340:323-33, 2010. PMID: 20309582
  • Jackson AR, Huang C-Y, Gu WY. Effect of Endplate Calcification and Mechanical Deformation on the Distribution of Glucose in Intervertebral Disc: A 3-D Finite Element Study. Computer Methods in Biomechanics and Biomedical Engineering, 14:195-204, 2011. PMID: 21337225
  • Yang Z, Huang C-Y, Candiotti KA, Zeng X, Yuan T-Y, Li J, Yu H, Abdi S. Sox-9 Facilitates Differentiation of Adipose Tissue-Derived Stem Cells Into A Chondrocyte-like Phenotype In Vitro. Journal of Orthopedic Research, 29:1291-7, 2011. PMID: 21400575.
  • Salvatierra JC, Yuan T-Y, Fernando HN, Castillo A, Gu WY, Cheung HS, Huang C-Y. Difference in Energy Metabolism of Annulus Fibrosus and Nucleus Pulposus Cells of The Intervertebral Disc. Cellular and Molecular Bioengineering, 4:302-310, 2011. PMID:21625336
  • Fernando HN, Czamanski J, Yuan T-Y, Gu WY, Huang C-Y. Mechanical Loading Affects the Energy Metabolism of Intervertebral Disc Cells. Journal of Orthopedic Research, 29:1634-41, 2011. PMID:21484859
  • Yuan T-Y, Huang C-Y, Gu WY. Novel Technique for Online Characterization of Cartilaginous Tissue Properties. Journal of Biomechanical Engineering, 133:094504, 2011. PMID: 22010750
  • Jackson AR, Huang C-Y, Brown, MD, Gu WY. 3D Finite Element Analysis of Nutrient Distributions and Cell Viability in the Intervertebral Disc: Effects of Deformation and Degeneration, Journal of Biomechanical Engineering. 133:091006, 2011. PMID: 22010741
  • Huang C-Y, Travascio F, Gu W-Y. Quantitative Analysis of Exogenous IGF-1 Administration of Intervertebral Disc Through Intradiscal Injection. Journal of Biomechanics, 45:1149-55, 2012. PMID: 22365501
  • Jackson AR, Yuan T-Y, Huang C-Y, Brown MD, Gu WY. Nutrient Transport in Human Annulus Fibrosus is Affected by Compressive Strain and Anisotropy. Annals of Biomedical Engineering, 40:2551-8, 2012. PMID: 22669503
  • Wang C, Huang C-Y, Lin W-C. Optical ATP Biosensor for Extracellular ATP Measurement, Biosensors and Bioelectronics, 43:355-361, 2013. PMID:23357001
  • Wang C, Gonzales SD, Levene H, Gu WY, Huang C-Y: Energy Metabolism of Intervertebral Disc under Mechanical Loading. Journal of Orthopedic Research, 31:1733-8, 2013. PMID: 23843186
  • Pelaez D, Huang C-Y, Cheung HS. Isolation of Pluripotent Neural Crest Derived Stem Cells from Adult Human Tissues by Connexin 43 Enrichment. Stem Cells and Development, 22:2906-14, 2013. PMID: 23750535
  • Vernon L, Abadin A, Wilensky D, Huang C-Y, Kaplan LD. Sub-Physiological Mechanical Loading Reduces Apoptosis Following Acute Impact Injury in a Porcine Cartilage Model. Sports Health, 6(1):81-8, 2014. PMID: 24427447
  • Mayo V, Sawatari Y, C-Y Huang C-Y, Garcia-Godoy F. Neural Crest-Derived Dental Stem Cells - Where We Are and Where We Are Going. Journal of Dentistry, 2014, in press. PMID: 24769107
  • Gonzales S, Rodriguez B, Barrera C, Huang C-Y. Measurement of ATP-Induced Transmembrane Potential Changes in IVD cells. Cellular and Molecular Bioengineering, in press

Selected conference abstracts:

  1. Flagler DJ, Huang C-Y, Yuan T-Y, Cheung HS, Gu WY. Response of CD24, Aggrecan and Collagen to Osmolarity and Glucose Concentrations in Cultured IVD Cells Measured by Flow Cytometry. The 55th Annual Meeting of the Orthopaedic Research Society, 2009.
  2. Yuan T-Y, Huang C-Y, Yang Z, Jackson A, Abdi S, Gu WY. Effect of Glucose Concentration on Glycosaminoglycan Accumulation in Alginate Culture of Rat Annulus Fibrosus Cells. The 55th Annual Meeting of the Orthopaedic Research Society, 2009.
  3. Yuan T-Y, Jackson A, Huang C-Y, Gu WY. Effect of Mechanical Loading on Oxygen Diffusivity in Annulus Fibrosus. Presented in The 55th Annual Meeting of the Orthopaedic Research Society, 2009.
  4. Huang C-Y, Gu WY. Distribution of Oxygen, Glucose and Lactate In Degenerated Intervertebral Disc. The ASME Summer Bioengineering Conference, 2009.
  5. Fernando HN, Czamanski J, Yuan T-Y, Gu WY, Huang C-Y. The Effect Of Static And Dynamic Loading On Energy Metabolism Of Annulus Fibrosus Cells. The 28th Scientific Conference of The Society for Physical Regulation in Biology and Medicine (SPRBM), 2010.
  6. Czamanski J, Yuan T-Y, Gu WY, Huang C-Y. Effect of Dynamic Compression on ATP Production and Release by Intervertebral Disc Cells. The 56th Annual Meeting of the Orthopaedic Research Society, 2010.
  7. Yang Z, Huang C-Y, Zeng X, Yuan TY, Li J, Abdi S. Constitutive Expression of Sox-9 Induces Differentiation of Adipose Tissue Derived Stem Cells into a Nucleus Pulposus Cell -Like Phenotype In Vitro. The 56th Annual Meeting of the Orthopaedic Research Society, 2010.
  8. Travascio F, Huang C-Y, Gu WY. Transport of Insulin-like Growth Factor 1 in Intervertebral Disc: Effect of Binding Interactions and Inhomogeneous Distribution of Binding Proteins in Annulus Fibrosus and Nucleus Pulposus. The ASME Summer Bioengineering Conference, 2010.
  9. Yuan TY, Fernando HN, Czamanski J, Wang C, Gu WY, Huang C-Y. Effect of Static Compression on Energy Metabolism of Porcine Intervertebral Disc. The ASME Summer Bioengineering Conference, 2010.
  10. Fernando H, Czamanski J, Yuan T-Y, Gu WY, Abdi S, Huang C-Y. Mechanical Loading Affects The Energy Metabolism of Intervertebral Disc Cells. The 57th Annual Meeting of the Orthopaedic Research Society, 2011.
  11. Travascio F, Huang C-Y, Gu WY. Growth Factor Therapy for Degenerated Intervertebral Disc. Quantitative Analysis of Protocols for Exogenous Administration of IGF-1 Through Intradiscal Injection. The 57th Annual Meeting of the Orthopaedic Research Society, 2011.
  12. Wang C, Yuan T-Y, Travascio F, Helbig M, Khoury K, Gu WY, Huang C-Y. Effect of Static Compression on ATP Production of Intervertebral Disc, The 57th Annual Meeting of the Orthopaedic Research Society, 2011.
  13. Yuan T-Y, Gonzales S, Castillo A, Jackson, AR, Huang C-Y, Gu WY, Novel Technique for Online Characterization of Cartilaginous Tissue in Bioreactor. The 57th Annual Meeting of the Orthopaedic Research Society, 2011.
  14. Wang C, Yuan T-Y, Gu WY, Huang C-Y. Difference in Lactate Accumulation and ATP Content of Annulus Fibrosus and Nucleus Pulposus Under Static Compression. The 29th Scientific Conference of The Society for Physical Regulation in Biology and Medicine (SPRBM), 2011.
  15. Wilensky D, Vernon L, Kaplan LD, Huang C-Y. Mechanical Loading In Vitro Promotes Chondrocyte Viability in Articular Cartilage of The Knee Following Single-Impact Injury. The 29th Scientific Conference of The Society for Physical Regulation in Biology and Medicine (SPRBM), 2011.
  16. Fernando HN, Czamanski J, 1Yuan T-Y, Gu WY, Huang C-Y. ATP Production and Release by Intervertebral Disc Cells under Mechanical Loading. Spine Research Symposium, Philadelphia Spine Research Society, 2011.
  17. Huang C-Y, Gu WY. Effect of Intradiscal IGF-1 Administration on Distributions of Glucose and Lactate in Intervertebral Disc. Spine Research Symposium, Philadelphia Spine Research Society, 2011.
  18. Scanlon C, Yuan T.Y, Echagarruga C, Huang C-Y, Gu WY. Verification of a Novel Technique for Online Characterization of Cartilaginous Tissue in Bioreactor. The 58th Annual Meeting of the Orthopaedic Research Society, 2012.
  19. Wang C, Gonzales S, Verne S, Gu WY, Huang C-Y. Effect of Dynamic Compression on ATP Production in Intervertebral Disc. The 58th Annual Meeting of the Orthopaedic Research Society, 2012.
  20. Huang C-Y, Gu WY. Intradiscal IGF-1 Administration May Not Improve Malnutrition in Intervertebral Disc. The 58th Annual Meeting of the Orthopaedic Research Society, 2012.
  21. Wang C, Gonzales SD, Gu WY, Huang C-Y. Accumulation of Extracellular ATP in Porcine Nucleus Pulposus. The ASME Summer Bioengineering Conference, 2012.
  22. Gonzales SD, Wang C, Genemaras AA, Huang C-Y. Novel Measuring System of ATP-induced Transmembrane Potential Change of Nucleus Pulposus Cells. The ASME Summer Bioengineering Conference, 2012.
  23. Vernon L, Wilensky D, Wang C, Kaplan L, Huang C-Y. Mechanical Loading Reduces Chondrocyte Death After Single Impact Injury Trauma. Porcine Knee Model. The ASME Summer Bioengineering Conference, 2012.
  24. Wang C, Gonzales SD, Gu WY, Huang C-Y. Effects of Mechanical Loading on Extracellular ATP Content in Porcine Nucleus Pulposus. The 59th Annual Meeting of the Orthopaedic Research Society, 2013
  25. Gonzales SD, Wang CC, Genemaras AA, Huang C-Y. Long-term ATP Treatment Stimulates Proteoglycan Accumulation by Intervertebral Disc Cells. The 59th Annual Meeting of the Orthopaedic Research Society, 2013
  26. Vernon L, Morel S, Abadin A, KaplanL, Huang C-Y, Mechanical Loading Increases Chondrocyte Viability After Impact Injury in Porcine Model. The 59th Annual Meeting of the Orthopaedic Research Society, 2013
  27. Gonzales SD, Wang C, Rodriguez B, Barrera C, Huang C-Y, Levene H. ATP Treatment promotes Collagen Deposition and Gene Expression in Intervertebral Disc Cells. The 60th Annual Meeting of the Orthopaedic Research Society, p. 1631, 2014.
  28. Vernon L, Vance D, Rampersaud E, Wang L, Vance J, Pericak-Vance M, Huang C-Y, Kaplan LD. Regional Differential Genetic Response of Human Articular Cartilage to Impact Injury. The 60th Annual Meeting of the Orthopaedic Research Society, p.0418 2014.
  29. Genemaras A, Bradshaw S, Kollefrath A, Zavala M, Huang C-Y, Kaplan LD. MicroRNA and mRNA Expression in Porcine Articular Cartilage after Single Intact Joint Impact Injury. The 60th Annual Meeting of the Orthopaedic Research Society, p1077, 2014.
Translate »