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Fabrice Manns

Photo of Fabrice Manns

Fabrice Manns

Professor and Chair | College of Engineering | Biomedical Engineering Department
Work Phone: (305) 284-2335


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Biography

Dr. Manns is a professor of biomedical engineering and ophthalmology and the chair of the Department of Biomedical Engineering, where he has also previously served as associate chairman and graduate program director. He has been a University of Miami faculty member since 1997. Manns divides his time between the Coral Gables campus and the Medical campus, where he is the co-director of Bascom Palmer Eye Institute’s Ophthalmic Biophysics Center. The Ophthalmic Biophysics Center is a research laboratory founded in 1970 by Prof. Jean-Marie Parel and is dedicated to the development of technologies designed to improve patient eye care. Manns leads a research program in the broad field of biomedical optics, including studies on the optics of the eye. His current research activities are the development of optical imaging and biometry systems to study the mechanism of accommodation and presbyopia and the relationship between the optics and anatomy of the eye to help optimize vision-correction procedures. He has also collaborated with clinicians on the development of laser and optical instrumentation for treatment or diagnosis of diseases in the fields of breast cancer, urology and otolaryngology. He has served as a lead investigator on both federally funded and industry-sponsored projects. Manns teaches undergraduate and graduate courses on medical imaging, biomedical optical instrumentation and imaging, medical applications of lasers, and optics of the eye. He also is an instructor in Bascom Palmer Eye Institute’s master’s program in visual science and investigative ophthalmology, where he coordinates a course on visual optics. Manns has been the chair of SPIE’s Ophthalmic Technologies Conference since 1997. He is an associate editor of the Optical Society of America’s Biomedical Optics Express journal and serves on the program committee of the annual meeting of the International Society for Imaging in the Eye. Manns received an electrical engineering degree from the Ecole Nationale Supérieure d’Electronique et de Radioélectricité de Bordeaux (now ENSEIRB MATMECA) and a post-graduate degree from the University of Bordeaux in microelectronics. He earned his PhD in biomedical engineering from the University of Miami. He completed a post-doctoral fellowship at Bascom Palmer Eye Institute sponsored by Fight for Sight before being hired as a faculty member jointly by the Department of Biomedical Engineering and the Department of Ophthalmology in 1997.

Research Interests

Laser applications in medicine, Biomedical optical imaging, Optics of the eye and vision correction, Ophthalmic technologies

HIGHER EDUCATION

    • University of Miami, Ph.D. in Biomedical Engineering. (1996)
    • University of Bordeaux I, Bordeaux, France, M.S. in Diplome d'Etudes Appronfondies. (1991)
    • Ecole Nationale Superieure d'Electronique et de Radioelectricite de Bordeaux, Bordeaux, France, B.S. in Electrical Engineering. (1991)

EXPERIENCE

    • University of Miami, Professor. College of Engineering (School of Medicine Secondary Appointment) (2013 - Present)
    • University of Miami, Co-Director. School of Medicine (2001 - Present)
    • University of Miami, Director. College of Engieering (1997 - Present)
    • University of Miami, Graduate Program Director. College of Engineering (2009 - 2016)
    • University of Miami, Associate Chairman. College of Engineering (2008 - 2016)
    • University of Miami, Acting Chair. College of Engineering (2013 - 2014)
    • University of Miami, Associate Professor (with tenure). College of Engineering (School of Medicine Secondary Appointment) (2006 - 2013)
    • University of Miami, Assistant Professor. College of Engineering (School of Medicine Secondary Appointment) (2000 - 2006)
    • University of Miami, Manager. School of Medicine (1995 - 2001)
    • University of Miami, Research Assistant Professor. College of Engineering (School of Medicine Secondary Appointment) (1997 - 2000)
    • University of Miami, Adjunct Instructor. College of Engineering (1996 - 1997)
    • University of Miami, Post-doctoral Associate. School of Medicine (1996 - 1997)
    • University of Miami, Graduate Research Assistant. College of Engineering (1992 - 1996)
    • University of Bordeaux I, Research Engineer. IXL Microelectronics Laboratory (1991 - 1992)
    • University of Bordeaux I, Research Assistant. IXL Microelectronics Laboratory (1991)
    • European Molecular Biology Laboratory, Heidelberg, Germany, Trainee. Confocal Microscopy Group (1990)

PUBLICATIONS

  • Juried or Refereed Journal Articles or Exhibitions

    • Wu, C., Han, Z., Wang, S., Li, J., Singh, M., Liu, C., Aglyamov, S., Emelianov, S., Manns, F., Larin, K. V. (2015).Assessing age-related changes in the biomechanical properties of rabbit lens using a co-aligned ultrasound and optical coherence elastography system. Investigative Ophthalmology and Visual Science, 56, 1292-1300.
    • De Freitas, C., Cabot, F., Culbertson, W., Yoo, S., Parel, J., Manns, F. (2015).Calculation of ophthalmic viscoelastic device-induced focus shift during femtosecond laser-assisted cataract surgery. Investigative Ophthalmology and Visual Science, 56, 1222-1227.
    • Maceo-Heilman, B., Manns, F., De Castro, A., Durkee, H., Arrieta, E., Marcos, S., Parel, J. (2015).Changes in monkey crystalline lens spherical aberration during simulated accommodation in a lens stretcher. Investigative Ophthalmology and Visual Science, 56, In Press (published online).
    • Pour, H. M., Kanapathipillai, S., Zarrabi, K., Manns, F., Ho, A. (2015).Stretch-dependent changes in surface profiles of the human crystalline lens during accommodation: A finite-element study. Clinical and Experimental Optometry, 98, 126-137.
    • Nankivil, D., Maceo, B., Durkee, H., Manns, F., Ehrmann, K., Kelly, S., Arrieta-Quintero, E., Parel, J. (2015).The zonules selectively alter the shape of the lens during accommodation based on the location of their anchorage points. Investigative Ophthalmology and Visual Science, 56, In Press (published online).
    • Marussich, L., Manns, F., Nankivil, D., Maceo Heilman, B., Yao, Y., Arrieta-Quintero, E., Ho, A., Augusteyn, R., Parel, J. (2015).Measurement of crystalline lens volume during accommodation in a lens stretcher. Investigative Ophthalmology and Visual Science, 56, 4239-4248.
    • Wang, S., Aglyamov, S., Karpiouk, A., Li, J., Emelianov, S., Manns, F., Lirin, K. (2013).Assessing the mechanical properties of tissue-mimicking phantoms at different depths as an approach to measure biomechanical gradient of crystalline lens. Biomedical Optics Express, 4(12), 2769-2780.
    • deFreitas, C., Ruggeri, M., Manns, F., Ho, A., Parel, J. (2013).In vivo measurement of the average refractive index of the human crystalline lens using optical coherence tomography. Optics Letters, 38, 85-87.
    • De Castro, A., Birkenfeld, J., Maceo, B., Arrieta, E., Manns, F., Parel, J., Marcos, S. (2013).Influence of shape and gradient refractive index in the accommodative changes of spherical aberration in non-human primate crystalline lenses. Investigative Ophthalmology and Visual Science, 54(9), 6197-6207.
    • Siedlecki, D., de Castro, A., Gambra, E., Ortiz, S., Borja, D., Uhlhorn, S., Manns, F., Marcos, S., Parel, J. (2012).Distortion correction of OCT images of the crystalline lens: Gradient-Index approach. Optometry and Vision Science, 89, E709-E718.
    • Hao, X., Jeffery, J., Le, T., McFarland, G., Johnson, G., Mulder, R., Garrett, Q., Manns, F., Nankivil, D., Arrieta, E., Ho, A., Parel, J., Hughes, T. (2012).High refractive index polysiloxane as injectable, in situ curable accommodating intraocular lens biomaterials. Biomaterials, 33, 5659-5671.
    • Ruggeri, M., Uhlhorn, S., De Freitas, C., Ho, A., Manns, F., Parel, J. (2012).Imaging and full-length biometry of the eye during accommodation using Spectral-Domain OCT with an optical switch. Biomedical Optics Express, 3, 1506-1520.
    • Augusteyn, R., Mohamed, A., Nankivil, D., Veerendranath, P., Arrieta, E., Taneja, M., Manns, F., Ho, A., Parel, J. (2011).Age-dependence of the optomechanical responses of ex vivo human lenses from India and the USA, and the force required to produce these in a lens stretcher: the similarity to in vivo disaccommodation. Vision Research, 51, 1667-1678.
    • de Castro, A., Siedlecki, D., Borja, D., Uhlhorn, S., Parel, J., Manns, F., Marcos, S. (2011).Age-dependent variation of the Gradient Index profile in human crystalline lenses. Journal of Modern Optics, 58, 1781-1787.
    • Maceo, B., Manns, F., Borja, D., Nankivil, D., Uhlhorn, S., Arrieta, E., Ho, A., Augusteyn, R., Parel, J. (2011).Contribution of the crystalline lens gradient refractive index to the accommodation amplitude in non?human primates: in vitro studies. Journal of Vision, 11, 13:23.
    • Ale, J., Manns, F., Ho, A. (2011).Magnifications of single and dual element accommodative intraocular lenses: Paraxial optics analysis. Ophthalmic and Physiological Optics, 31, 7-16.
    • Ale, J., Manns, F., Ho, A. (2011).Paraxial analysis of the depth-of-field of a pseudophakic eye implanted with Accommodating IOLs. Optometry and Vision Science, 88, 789-794.
    • Chou, T., Kocaoglu, O., Borja, D., Ruggeri, M., Uhlhorn, S., Manns, F., Porciatti, V. (2011).Postnatal elongation of eye size in DBA/2J mice compared with C57BL/6J mice: In vivo analysis with whole-eye OCT. Investigative Ophthalmology and Visual Science, 52, 3604-3612.
    • Ziebarth, N., Arrieta, E., Moy, V., Manns, F., Parel, J. (2011).Primate lens capsule elasticity assessed using Atomic Force Microscopy. Experimental Eye Research, 92, 490-494.
    • Urs, R., Ho, A., Manns, F., Parel, J. (2010).Age-dependent Fourier model of the shape of the isolated ex vivo human crystalline lens. Vision Research, 50, In press.
    • Borja, D., Siedlecki, D., De Castro, A., Uhlhorn, S., Ortiz, S., Arrieta, E., Parel, J., Marcos, S., Manns, F. (2010).Distortions of the posterior surface in optical coherence tomography images of the isolated crystalline lens: Effect of the lens index gradient. Biomedical Optics Express, 1, 1331-1340.
    • Ale, J., Manns, F., Ho, A. (2010).Evaluation of the performance of accommodating IOL using paraxial optics analysis. Ophthalmic and Physiological Optics, 30, 132-142.
    • Borja, D., Manns, F., Ho, A., Ziebarth, N., Acosta, A. C., Arrieta, E., Augusteyn, R. C., Parel, J. M. (2010).Optical power and biometric properties of the non-human primate isolated crystalline lens. Investigative Ophthalmology and Visual Science, 51, 2118-2125.
    • Fedke, C., Manns, F., Ho, A. (2010).The entrance pupil of the human eye: a three-dimensional model as a function of viewing angle. Optics Express, 18, 22364-22376.
    • Nankivil, D., Manns, F., Arrieta-Quintero, E., Ziebarth, N., Borja, D., Amelinckx, A., Bernal, A., Ho, A., Parel, J. M. (2009).Effect of anterior zonule transection on the change in lens diameter and power in cynomolgus monkeys during simulated accommodation. Investigative Ophthalmology and Visual Science, 50, 4017-4021.
    • Urs, R., Manns, F., Ho, A., Borja, D., Amelinckx, A., Smith, J., Jain, R., Augusteyn, R., Parel, J. M. (2009).Shape of the isolated ex-vivo human crystalline lens. Vision Research, 49, 74-83.
    • Yoo, S., Kymionis, G., Deobhakta, A., Ide, T., Manns, F., Culbertson, W., O'Brien, T., Alfonso, E. (2008).One-year results and anterior segment Optical Coherence Tomography findings of Descemet Stripping Automated Endothelial Keratoplasty combined with phacoemulsification. Archives of Ophthalmology, 126, 1052-1055.
    • Borja, D., Manns, F., Ho, A., Ziebarth, N., Rosen, A., Jain, R., Amelinckx, A., Arrieta, E., Augusteyn, R., Parel, J. (2008).Optical power of the isolated human crystalline lens. Investigative Ophthalmology and Visual Science. NONE, 49, 2541-2548.
    • Uhlhorn, S., Borja, D., Manns, F., Parel, J. (2008).Refractive index measurement of the isolated crystalline lens using optical coherence tomography. Vision Research, 48, 2732-2738.
    • Ziebarth, N., Wojcikiewicz, E., Manns, F., Moy, V., Parel, J. (2007).Atomic Force Microscopy measurements of lens elasticity in monkey eyes. Molecular Vision, 13, 504-510.
    • Manns, F., Parel, J., Denham, D., Billotte, C., Ziebarth, N., Borja, D., Fernandez, V., Arrieta, E., Aly, M., Ho, A., Holden, B. (2007).Optomechanical response of human and monkey lenses in a lens stretcher. Investigative Ophthalmology and Visual Science, 48, 3260-3268.
    • Kocaoglu, O., Uhlhorn, S., Hernandez, E., Juarez, R., Will, R., Parel, J., Manns, F. (2007).Simultaneous fundus imaging and optical coherence tomography of the mouse retina. . Investigative Ophthalmology and Visual Science, 48, 1283-1289.
    • Parel, J., Ziebarth, N., Denham, D., Fernandez, V., Manns, F., Lamar, P., Rosen, A., Ho, A., Erickson, P. (2006).Assessment of the strength of mini-capsulorhexes. Journal of Cataract and Refractive Surgery, 32, 1366-1373.
    • Bernal, A., Parel, J., Manns, F. (2006).Evidence for posterior zonular fiber attachment on the anterior hyaloid membrane. Investigative Ophthalmology and Visual Science, 47, 4708-4713.
    • Rosen, A., Denham, D., Fernandez, V., Borja, D., Ho, A., Manns, F., Parel, J., Augusteyn, R. (2006).In vitro lens dimensions and curvatures of human lenses. Vision Research, 46, 1002-1009.
    • Ho, A., Manns, F., Pham, T., Parel, J. (2006).Predicting the performance of accommodating intra-ocular lenses using ray-tracing.. Journal of Cataract and Refractive Surgery, 32, 129-136.
    • Ziebarth, N., Manns, F., Parel, J. (2005).Fiber-optic focus detection system for non-contact high resolution thickness measurement of transparent tissues. Journal of Physics D: Applied Physics, 38, 2708-2715.
    • Ziebarth, N., Manns, F., Uhlhorn, S., Venkatraman, A., Parel, J. (2005).Non-contact optical measurement of lens capsule thickness in human, monkey, and rabbit postmortem eyes. Investigative Ophthalmology and Visual Science, 46, 1690-1697.
    • Yavuz, E., Morawski, K., Telischi, F., Ozdamar, O., Delgado, R., Manns, F., Parel, J. (2005).Simultaneous measurement of electrocochleography and cochlear blood flow during cochlear hypoxia in rabbits. Journal of Neuroscience Methods., 147, 55-64.
    • Borja, D., Manns, F., Lamar, P., Rosen, A., Fernandez, V., Parel, J. (2004).Preparation and hydration control of corneal tissue strips for experimental use. Cornea, 23, 61-66.
    • Manns, F., Fernandez, V., Zipper, S., Sandadi, S., Hamaoui, M., Ho, A., Parel, J. (2004).Radius of curvature and asphericity of the anterior and posterior surface of human cadaver crystalline lenses. Experimental Eye Research, 78, 39-51.
    • Salas, N., Manns, F., Milne, P., Denham, D., Minhaj, A., Parel, J., Robinson, D. (2004).Thermal analysis of laser interstitial thermotherapy in ex-vivo fibro-fatty tissue using exponential functions. Physics in Medicine and Biology, 49, 1609-1624.
    • Manns, F., Borja, D., Parel, J., Smiddy, W., Culbertson, W. (2003).Semi-analytical thermal model for sub-ablative laser heating of homogeneous non-perfused biological tissue: Application to laser thermokeratoplasty. Journal of Biomedical Optics, 8, 288-297.
    • Manns, F., Ho, A., Parel, J., Culbertson, W. (2002).Ablation profiles for wavefront-guided correction of myopia and primary spherical aberration. Journal of Cataract and Refractive Surgery, 28, 766-774.
    • Mizota, A., Takasoh, M., Kobayashi, K., Parel, J., Manns, F., Rol, P. (2002).Internal sclerostomy with the Er:YAG laser using a gradient-index (GRIN) endoscope. Ophthalmic Surgery and Lasers, 33, 214-220.
    • Minhaj, A., Manns, F., Milne, P., Denham, D., Salas, N., Nose, I., Damgaard-Iversen, K., Parel, J., Robinson, D. (2002).Laser interstitial thermotherapy (LITT) monitoring using high-resolution digital mammography: Theory and experimental studies. Physics in Medicine and Biology, 47, 2987-2999.
    • Manns, F., Milne, P., Parel, J. (2002).UV corneal photoablation. Journal of Refractive Surgery, 18, S610-S614.
    • Ho, A., Erickson, P., Manns, F., Pham, T., Parel, J. (2001).Theoretical analysis of accommodation amplitude and ametropia correction by varying refractive index in phaco-ersatz. Optometry and Vision Science, 78, 405-410.
    • Milne, P., Parel, J., Manns, F., Denham, D., Gonzalez-Cirre, X., Robinson, D. (2000).Development of stereotactically-guided laser interstitial thermotherapy (LITT) of breast cancer: in-situ measurement and analysis of the temperature field in ex vivo and in vivo adipose tissue. Lasers in Surgery and Medicine, 26, 67-75.
    • Rol, P., Huber, C., Manns, F., Parel, J. (1999).ArF Photoablation of Keratoprostheses. Annales Instituto Barraquer (Barcelona), 28, 127-130.
    • Manns, F., Milne, P., Gonzalez-Cirre, X., Denham, D., Parel, J., Robinson, D. (1998).In-situ temperature measurements with thermocouple probes during laser interstitial thermotherapy (LITT): Quantification of a measurement artifact. Lasers in Surgery and Medicine, 23, 94-103.
    • Robinson, D., Parel, J., Denham, D., Gonzalez-Cirre, X., Manns, F., Milne, P., Schachner, R., Herron, A., Comander, J., Hauptman, G. (1998).Interstitial laser hyperthermia model development for minimally invasive therapy of breast carcinoma. Journal of the American College of Surgeons, 186, 284-292.
    • Sasoh, M., Parel, J., Manns, F., Nose, I., Comander, J., Smiddy, W. (1998).Quantification of Ho:YAG and Tm:YAG laser-induced scleral shrinkage for buckling procedures. Ophthalmic Surgery and Lasers, 29, 410-421.
    • Shen, J., Joos, K., Manns, F., Denham, D., Ren, Q., Fankhauser, F., Soderberg, P., Parel, J. (1997).Ablation rate of cornea and PMMA with a frequency-quintupled Nd:YAG laser. Lasers in Surgery and Medicine, 21, 179-185.
    • Yamanaka, A., Miyazaki, S., Manns, F., Hayashi, H., Parel, J. (1997).In vitro study of laser photo-ablative optic nerve sheath decompression with the Erbium:YAG and Thulium:YAG lasers. Acta Medica Hyogoensia, 22, 251-257.
    • Manns, F., Rol, P., Shen, J., Soderberg, P., Matsui, T., Parel, J. (1996).Optical profilometry of poly(methylmethacrylate) (PMMA) surfaces after reshaping with a scanning photorefractive keratectomy (SPRK) system. Applied Optics, 35, 3338-3346.
    • Robinson, D., Parel, J., Denham, D., Manns, F., Gonzalez, X., Schachner, R., Herron, A., Burdette, E. (1996).Stereotactic uses beyond core biopsy: model development for minimally invasive treatment of breast cancer through interstitial laser hyperthermia. American Surgeon, 62, 117-118.
    • Manns, F., Shen, J., Söderberg, P., Matsui, T., Parel, J. (1995).Development of an algorithm for corneal reshaping with a scanning beam. Applied Optics, 34, 4600-4608.
  • Refereed Books

    • Manns, F. (Ed.) The correction of ametropia by photoablation of the cornea with a scanning beam. University of Miami Dissertation.

    Book Chapters

    • Dawson, D., Manns, F., Lee, Y., (2008). Principles and Ablation Profiles: Myopia, Hyperopia, and Astigmatism; Chapter 88 . Corneal Surgery, Theory, and Technique and Tissue, Fourth Edition (pp. ). Mosby-Elsevier, Philadelphia.
    • Parel, J., Manns, F., Holden, B., Ho, A., (2006). Refractive surgical procedures to restore accommodation; Chapter 40 . Refractive Surgery, 2nd Edition (pp. 501-509). Mosby-Elsevier, Philadelphia.
    • Manns, F., Ho, A., , . (2004). Chapter 42. Customized visual correction of presbyopia in Wavefront-guided corrections: The quest for super vision, 2nd Edition (pp. 353-360). SLACK Inc, Thorofare, NJ.
    • Ho, A., Erickson, P., Manns, F., Fernandez, V., Parel, J., (2003). The limits of simultaneous ametropia correction in phaco-ersatz . Hyperopia and Presbyopia (pp. 259-277). Marcel Dekker, New York.